Results 121 to 130 of about 630,227 (329)

Reducing the uncertainty in projections of future ice shelf basal melting [PDF]

, 2014
Simulations of ice-shelf basal melting in future climate scenarios from the IPCC’s Fourth Assessment Report (AR4) have revealed a large uncertainty and the potential of a rapidly increasing basal mass loss particularly for the large cold-water ice ...
Hellmer, Hartmut, Kauker, Frank, Timmermann, Ralph, van de Berg, W. J.   +3 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Fracture criteria and tensile strength for natural glacier ice calibrated from remote sensing observations of Antarctic ice shelves

Journal of Glaciology
The conditions under which ice fractures and calves icebergs from Antarctic ice shelves are poorly understood due largely to a lack of relevant observations. Though previous studies have estimated the stresses at which ice fractures in the laboratory and
Sarah Wells-Moran, Meghana Ranganathan, Brent Minchew   +2 more
doaj   +1 more source

The Water Budget in Antarctica [PDF]

, 1967
Nearly the whole Antarctic ice sheet, including the attached ice shelves, shows a net accumulation. Factors other than precipitation influence the budget only to a small degree.
F. Loewe
core   +1 more source

Deformation of Floating Ice Shelves [PDF]

Journal of Glaciology, 1957
AbstractThe problem of the creep deformation of floating ice shelves is considered. The problem is solved using Glen’s creep law for ice and Nye’s relation of steady-state creep (the analogue of the Lévy-Miles relation in plasticity theory). Good agreement is obtained between an observed creep rate at Maudheim in the Antarctic and that predicted from ...
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mechanical analysis of pinning points in the Ross Ice Shelf, Antarctica

Annals of Glaciology, 2019
Ice shelves regulate the rate of ice-sheet discharge along much of the Antarctic coastline. Pinning points, sites of localised grounding within floating ice, can in turn, regulate the flow and thickness of an ice shelf.
Holly Still, Adam Campbell, Christina Hulbe   +2 more
doaj   +1 more source

Dynamic changes on the Wilkins Ice Shelf during the 2006–2009 retreat derived from satellite observations [PDF]

, 2017
The vast ice shelves around Antarctica provide significant restraint to the outflow from adjacent tributary glaciers. This important buttressing effect became apparent in the last decades, when outlet glaciers accelerated considerably after several ice ...
Braun, Matthias, Fürst, Johannes, Humbert, Angelika, Rankl, Melanie   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source