Results 221 to 230 of about 69,716 (313)

Vertical motions in clouds from EarthCare satellite and a global storm-resolving modeling. [PDF]

Sci Rep
Roh W, Satoh M, Matsugishi S, Aoki S, Kubota T, Okamoto H.   +5 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Creep Characteristics and Damage Constitutive Model of White Sandstone Under Short-Term Freeze-Thaw Cycles. [PDF]

Materials (Basel)
Zhang H, Li Y, Zeng P, Zhao K, Shen D, Yang X.   +5 more
europepmc   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Ice-sheet hydro-fracture not advanced inland by lower-elevation lake drainages in Kalaallit Nunaat. [PDF]

Nat Commun
Stevens LA, Nettles M, Larochelle S, Okal M, Falconer E, Turner N, Rines J, Lai CY, Lu G.   +8 more
europepmc   +1 more source

Estimation of Sea Ice Drift Velocity

, 2013
The Arctic is an important region containing large amount of unused potential. It is expected that a large amount of the worlds undiscovered oil and gas resources are located here, and the shortest route between northern Europe and eastern Asia called the Northern Sea Route (NSR) goes through the area.
openaire   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Fracture-based grasping: dynamic impact enables predictable robotic anchoring to freshwater ice. [PDF]

Npj Robot
Galassi A, Trebi-Ollennu A, Papadopoulos P, Stuart HS.   +3 more
europepmc   +1 more source

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, EarlyView.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source

Magnetogravitationally regulated streamer accretion onto a class 0 protostellar system. [PDF]

Sci Adv
Huang B, Girart JM, Stephens IW, Megeath T, Le Gouellec VJM, Murillo NM, Cortés P, Fernández-López M, Li ZY, Looney LW, López-Vázquez JA, Pineda JE, Sánchez-Monge Á, Sanhueza P, Sadavoy S, Zhang Q, Hull CLH, Karnath N, Liang E, Myers PC.   +19 more
europepmc   +1 more source