Results 71 to 80 of about 2,856 (282)

NASA's aircraft icing technology program [PDF]

NASA' Aircraft Icing Technology program is aimed at developing innovative technologies for safe and efficient flight into forecasted icing. The program addresses the needs of all aircraft classes and supports both commercial and military applications ...
Reinmann, John J.
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Wind Tunnel Tests on Aerodynamic Characteristics of Ice-Coated 4-Bundled Conductors [PDF]

, 2017
Wind tunnel tests were carried out to obtain the static aerodynamic characteristics of crescent iced 4-bundled conductors with different ice thicknesses, initial ice accretion angles, bundle spaces, and wind attack angles.
Li Xin-min, Nie Xiao-chun, Yan Zhi-tao, You Yi, Zhu Yong-kun   +4 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Principles of Mechanical Design in Overhead Transmission Lines [PDF]

, 2016
Technical infrastructures are of significant importance for a modern society to develop continuously, and dependence of society to electric power is ever-increasing.
Setayeshgar, Armin
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

A third-order characteristic-based-split finite element scheme of Spalart–Allmaras model and its application to flow past crescent iced 4-bundled conductors

Advances in Aerodynamics
The one-equation Spalart–Allmaras (SA) model is employed to close the Reynolds averaged Navier–Stokes equations (RANS equations), and research on turbulent numerical algorithm is carried out.
Shaokai Liao, Liqiang Wang, Guangying Yang, Wenhao Lin   +3 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Diameter correction coefficient of ice thickness on conductors at natural ice observation stations

IET Generation, Transmission & Distribution, 2014
In the construction or reconstruction of transmission lines for cold climate region, selection of ice thickness design criterion is an important factor to improve the lines anti‐icing performance. Indeed if the designed ice thickness selection is excessively thin, it is hard for the conductors to keep safe and stable operation ...
Jiang Xingliang, Dong Bingbing, Chao Yafeng, Zhang Zhijin, Hu Qin, Hu Jianlin, Shu Lichun   +6 more
openaire   +1 more source