Duration Identification Method for Wire Icing Process Based on Fisher Criterion
南方能源建设[Objective] To analyze the critical meteorological conditions for conductor icing and melting, accurately predict the start and end times of conductor icing, and provide a basis for power departments to prevent icing disasters.
Rong ZHANG, Ti DU, Pengjie SUN
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
The Icing Characteristics of Post Insulators in a Natural Icing Environment
AtmosphereIcing significantly reduces the electrical performance of insulators, and grid failures caused by insulator icing are common. Currently, most research on the flashover characteristics of insulators under icing conditions focuses on artificially iced ...
Zhijin Zhang +4 more
doaj +1 more source
Droplet Size Distribution and Liquid Water Content Monitoring in Icing Conditions with the ICEMET Sensor [PDF]
, 2019 Field measurement results from a novel optical cloud droplet monitoring sensor designed for icing conditions monitoring are presented. The sensor has been demonstrated at two sites in northern Finland; first at Global Atmosphere Watch Station in Pallas ...
Mäkynen, Anssi J. +2 more
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Development of a Stable TiO2 Nanocomposite Self-Cleaning Coating for Outdoor Applications
Advances in Materials Science and Engineering, 2016 A convenient and low-cost approach for the elaboration of a stable superhydrophobic coating is reported, involving the use of TiO2 nanoparticles via the spray coating method.
F. Madidi, G. Momen, M. Farzaneh
doaj +1 more source
ICS-LTU2022: A dataset for ICS vulnerabilities
Computers & Security, 2023 Manar Alanazi +2 more
openaire +2 more sources
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source