Results 61 to 70 of about 119,197 (258)

The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase eta [PDF]

, 2016
Several important anti-tumor agents form DNA interstrand crosslinks (ICLs), but their clinical efficiency is counteracted by multiple complex DNA repair pathways.
Anjali Sharma, Ekaterina G. Frank, Guainazzi, Ho, Orlando D. Schärer, Shivam Mukherjee, Upasana Roy   +6 more
core   +1 more source

Nano‐Gs‐Protein Peptidomimetika: Rationales Design von Peptiden, die vom C‐Terminus von Gα abgeleitet sind und Schlüsselkomponenten der Gs‐β2AR‐Wechselwirkungen nachahmen

Angewandte Chemie, EarlyView.
G Protein‐gekoppelte Rezeptoren (GPCRs) sind wichtige therapeutische Zielstrukturen. Die Modulation der GPCR‐Aktivität über intrazelluläre Bindungsstellen gewinnt zunehmend an Bedeutung. Ein strukturell und computergestützter Ansatz ermöglichte die Entwicklung kleiner, vom G Protein abgeleiteter Peptidomimetika, die gezielt an die intrazelluläre ...
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

Dark energy survey year 1 results: detection of intracluster light at redshift ∼ 0.25 [PDF]

, 2019
International audienceUsing data collected by the Dark Energy Survey (DES), we report the detection of intracluster light (ICL) with ∼300 galaxy clusters in the redshift range of 0.2–0.3.
Abbott, TMC, Annis, J, Avila, S, Bertin, E, Brooks, D, Burke, DL, Carnero Rosell, A, Carretero, J, Collaboration, DES, Collins, C, Cunha, CE, D Andrea, CB, da Costa, LN, De Vicente, J, Desai, S, Diehl, HT, Dietrich, JP, Doel, P, Drlica-Wagner, A, Eifler, TF, Evrard, AE, Flaugher, B, Fosalba, P, Frieman, J, Garcia-Bellido, J, Gaztanaga, E, Gerdes, DW, Gruen, D, Gruendl, RA, Gschwend, J, Gutierrez, G, Hartley, WG, Hilton, M, Hollowood, DL, Honscheid, K, Hoyle, B, James, DJ, Jeltema, T, Kind, M Carrasco, Kuehn, K, Kuropatkin, N, Leung, Y, Li, TS, Lima, M, Maia, MAG, March, M, Marshall, JL, Melchior, Peter M, Menanteau, F, Miller, CJ, Miquel, R, Mohr, JJ, Ogando, RLC, Palmese, A, Plazas, AA, Romer, AK, Rykoff, ES, Sanchez, E, Scarpine, V, Schubnell, M, Serrano, S, Sevilla-Noarbe, I, Smith, M, Soares-Santos, M, Sobreira, F, Suchyta, E, Swanson, MEC, Tarle, G, Thomas, D, To, C, Wester, W, Yanny, B, Zhang, Y   +72 more
core   +8 more sources

Nano‐Gs Protein Peptidomimetics: Rational Design of Gα C‐Terminus‐Derived Peptides Mimicking Key Components of Gs‐β2AR Interactions

Angewandte Chemie International Edition, EarlyView.
G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

Complexity Analysis of Bubble Plumes in Power Law Fluids Based on Chaos Theory

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT In order to reveal the complexity of the internal flow of bubble plume in power law fluid, the flow characteristics and chaotic characteristics of plume are studied by experiment and theory. The chaotic characteristic parameters (correlation dimension D, K entropy, and Lyapunov exponent λ) of gas velocity under different superficial gas ...
Xin Dong, Chong Dong, Can Xue, Meiheng Peng, Ying Feng, Jianwei Zhang, Yinuo Liu   +6 more
wiley   +1 more source

Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway

Cell Reports, 2017
Summary: DNA interstrand crosslinks (ICLs) that are repaired in non-dividing cells must be recognized independently of replication-associated DNA unwinding. Using cell-free extracts from Xenopus eggs that support neither replication nor transcription, we
Niyo Kato, Yoshitaka Kawasoe, Hannah Williams, Elena Coates, Upasana Roy, Yuqian Shi, Lorena S. Beese, Orlando D. Schärer, Hong Yan, Max E. Gottesman, Tatsuro S. Takahashi, Jean Gautier   +11 more
doaj   +1 more source

The skeleton of the green Iguana iguana (Squamata: Iguanidae) and its intraspecific morphological variation

The Anatomical Record, EarlyView.
Abstract The green iguana (Iguana iguana) is an iguanine lizard with herbivorous and arboreal habits, whose distribution spans through South America, Central America to the south of North America. Although the genus Iguana is well‐known, the species still lacks a comprehensive and up‐to‐date anatomical study, particularly addressing the axial skeleton,
Vieno Rosa, Marcos Vinícius Coelho, Camila Cupello   +2 more
wiley   +1 more source

Osteohistology of two phorusrhacids reveals uninterrupted growth strategy

The Anatomical Record, EarlyView.
Abstract Phorusrhacidae were apex predators that primarily dominated South America ecosystems for at least 40 million years with their imposing size and predatory lifestyle—yet some aspects of their biology remain poorly understood. Osteohistology is a tool for understanding growth dynamics and biomechanical adaptations.
Lotta Dreyer, Christian Cooper, Jingmai O'Connor   +2 more
wiley   +1 more source

Buffering zone of implantable Collamer lens sizing in V4c

BMC Ophthalmology, 2017
Background The purpose of this study was to identify factors related to the unexpected vault in V4c implantable collamer lens (ICL; STAAR Surgical) implantation. Methods V4c ICLs were implanted in 43 eyes of 43 patients for the correction of myopia.
Seung Wan Nam, Dong Hui Lim, Joo Hyun, Eui-Sang Chung, Tae-Young Chung   +4 more
doaj   +1 more source

Annotating aspects in text and image: A new task and dataset for multimodal aspect‐based sentiment analysis

Journal of the Association for Information Science and Technology, EarlyView.
Abstract Aspect‐Based Sentiment Analysis (ABSA) has evolved from textual analysis to a multimodal paradigm, integrating visual information to capture nuanced sentiments. Despite advancements, existing Multimodal ABSA (MABSA) research remains limited in granularity, which focuses on either coarse‐level categories or named entities, neglecting fine ...
Li Yang, Jia Yang, Jin‐Cheon Na, Jianfei Yu   +3 more
wiley   +1 more source