Results 11 to 20 of about 665 (169)

Development of a Next-Generation Sequencing Protocol for Assessing Lenacapavir Resistance in HIV-1 Capsid. [PDF]

J Med Virol
ABSTRACT Lenacapavir (LEN) is a first‐in‐class capsid inhibitor (CAI) that targets multiple stages of the HIV‐1 lifecycle, showing efficacy in heavily treatment‐experienced (HTE) individuals with multidrug‐resistance (MDR) and in pre‐exposure prophylaxis (PrEP). This study aimed to characterize a novel in‐house next‐generation sequencing (NGS) protocol
El Khalili O, Chenwi CA, Spalletta D, Marchegiani G, Carioti L, Moghadam HE, Bertoli A, Spagnuolo V, Santoro MM, Ceccherini-Silberstein F, Bellocchi MC.   +10 more
europepmc   +2 more sources

Achieving reimbursable PrEP is insufficient to increase and diversify the users attending community-based services. [PDF]

HIV Med
Abstract Objectives The reimbursement of HIV pre‐exposure prophylaxis (PrEP) in Italy was expected to increase uptake and diversify users. We assessed changes in PrEP initiation patterns before and after reimbursement at a community‐based service. Methods We conducted a monocentric retrospective cohort study that included all individuals who initiated ...
Caruso E, Tavelli A, De Bona A, Frattini N, Moschese D, Muccini C, Tesoro D, Soria AG, Bianchi A, Monforte AA, Cernuschi M, Rossotti R.   +11 more
europepmc   +2 more sources

Safety and effectiveness of switch to bictegravir/emtricitabine/tenofovir alafenamide following dual regimen therapy in people with HIV: Insights from the Icona cohort. [PDF]

HIV Med
Abstract Objectives Most treatment switches are for simplification from three‐drug (3DR) to dual regimens (2DR). However, a proportion of people with HIV may switch back to 3DR, like bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) after 2DR.
De Vito A, Tavelli A, Cozzi-Lepri A, Giacomelli A, Rossotti R, Ponta G, Bobbio N, Ianniello A, Cingolani A, Madeddu G, Antinori A, d'Arminio Monforte A, ICONA Foundation Study Group.   +12 more
europepmc   +2 more sources

Marine Heatwaves, Ocean Warming and Acidification Reshape Reef Fish Gut Microbiomes. [PDF]

Mol Ecol
ABSTRACT Extreme climatic events and gradual climate change are increasingly anticipated to interact and reshape ecological communities. However, the combined effects of ocean warming, acidification and marine heatwaves on host‐associated microbial communities and their potential role in host adaptation remain poorly understood.
Mitchell A, Hayes C, Hudson CJ, Connell SD, Harvey BP, Agostini S, Jolly J, Ravasi T, Booth DJ, Nagelkerken I.   +9 more
europepmc   +2 more sources

Range-extending fish become competitive dominants under ocean warming but not heatwaves or acidification. [PDF]

Ecology
Abstract Ocean warming is driving species range extensions into cooler regions. The direct physiological influence of warming on species performance can accelerate such extensions into novel ecosystems; however, indirect effects of invader–resident interactions in cooler regions may counter these positive effects.
Mitchell A, Coni EOC, Connell SD, Booth DJ, Harvey BP, Agostini S, Ravasi T, Nagelkerken I.   +7 more
europepmc   +2 more sources

Integrating Remote Sensing with SCS and ICONA Models for Mapping Land Degradation in Fars Province

علوم آب و خاک, 2022
The objective of the present study was to investigate the performance of some of the extracted information for mapping land degradation using remote sensing and field data in Fras province.
S. Dehghan Farsi, R. Jafari, A.R. Mousavi   +2 more
doaj  

La mesquita genèrica : principis de disseny per projectar una mesquita

Temes de Disseny, 2008
El concepte de "mesquita genèrica" investiga la representació de la pràctica islàmica contemporània en un context laic i explora la idea de la mesquita com a espai multifuncional a través dels anomenats "principis de disseny generatiu", una sèrie de ...
Azra Aksamija
doaj   +4 more sources

Fincas mayores en la provincia de Jaén 1979: estructuras regionales y agrarias del mediano y gran latifundio en una fase de cambio radical en España

Estudios Geográficos, 2011
El artículo analiza el panorama estadístico de 507 fincas de gran y mediano latifundio. Se diferencian las superficies agrarias según sus aprovechamientos.
Konrad Tyrakowski Findeiss
doaj   +1 more source

Conceptos para una sociología del paisaje

Papers, 2010
El paisaje ha sido un gran olvidado dentro de la tradición sociológica como un producto y como fuerza activa en la producción social. El paisaje también es sociedad y las formas como se interpreta, las manera a través de las que interaccionamos con él y ...
José Manuel Echavarren
doaj   +1 more source

Long-acting injectable cabotegravir and rilpivirine in observational cohort studies: A systematic review on virological failure, resistance and re-suppression outcomes in virally suppressed individuals living with HIV. [PDF]

HIV Med
Abstract Introduction Randomized controlled trial evidence suggests that long‐acting injectable (LA‐I) cabotegravir and rilpivirine (CAB+RPV) has similar virological failure (VF) rates to daily oral therapy, but clinical practice evidence is lacking. Integrase inhibitor (INI) resistance may limit future therapy.
Ring K, Elias A, Devonald M, Smuk M, Orkin C.   +4 more
europepmc   +2 more sources