Results 191 to 200 of about 117,111 (323)

ICOSL: more than a trigger of ICOS function. [PDF]

Cell Commun Signal
Stoppa I, Provera A, Sacchetti S, Clemente N, Pantham D, Christaki F, Vecchio C, Sheferaw AN, Rolla R, Dianzani C, Sutti S, Dianzani U.   +11 more
europepmc   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Exploring Anti-Neoplastic Activity of Chitosan Nanobubbles Decorated with ICOS-Fc and Loaded with Paclitaxel in a Human and Murine Model of Melanoma. [PDF]

Pharmaceutics
Pantham D, Argenziano M, Christaki F, Clemente N, Colombo C, Benetti E, Pizzimenti S, Dianzani U, Stoppa I, Cavalli R, Dianzani C.   +10 more
europepmc   +1 more source

First ICOS Release: ICOS Alfa version

Delivery of the ICOS alfa release also reporting on the technical performance ...
openaire   +1 more source

Growth in Production and Environmental Deposition of Trifluoroacetic Acid Due To Long‐Lived CFC Replacements and Anesthetics

Geophysical Research Letters, Volume 53, Issue 3, 16 February 2026.
Abstract Trifluoroacetic acid (TFA) is a persistent pollutant with potential long‐term effects on the environment and on health. Recent studies using ice core records report large increases (up to tenfold) in Arctic TFA deposition since the 1970s, and trends suggest long‐lived chlorofluorocarbon (CFC) replacements may be a major source.
Lucy Hart, Ryan Hossaini, Oliver Wild, Andrea Mazzeo, Crispin Halsall, Xuewei Hou, Zihao Wang, Martyn P. Chipperfield, Jgor Arduini, Paul B. Krummel, Chris R. Lunder, Jens Mühle, Simon O’Doherty, Sunyoung Park, Stefan Reimann, Kieran M. Stanley, Ray F. Weiss, Dickon Young   +17 more
wiley   +1 more source

Activated circulating T follicular helper 17 cells positively correlated with anti-HBV humoral immunity in chronic hepatitis B patients. [PDF]

Front Microbiol
Gu Q, Mao M, Liu Y, Tong X, Zhang J, Ran J, Ma X, Xia J, Huang R, Li J, Liu T, Chen Y, Yin S, Wu C.   +13 more
europepmc   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

The role of immune checkpoint molecules in cancers. [PDF]

Front Immunol
Zhang M, Xu J, Zheng Z, Guo Z, Wang H, Zhou M, Tang H, Zhu L.   +7 more
europepmc   +1 more source

Single‐Cell Profiling: Any Scale, Any Size, All at Once

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Traditional single‐cell technologies are constrained by cellular dimension and throughput scale, in addition to its inability preserve spatial information. With recent innovations, these technologies now allow high throughput, large‐sized cell, and multi‐modal profiling of patient samples, overcoming these limitations.
Denise Goh, Felicia Wee, Rachel Elizabeth Ann Fincham, Ruisi Li, Joe Yeong   +4 more
wiley   +1 more source

A Potential Approach of Mesenchymal Stem Cells Combined Silybin for Synergistic Treatment in Rheumatoid Arthritis via ICOS/ICOSL. [PDF]

MedComm (2020)
Wang YC, Ding S, Wang YF, Xie H, Shan Liu S, Chen HW, Wu D, Xie Y, Wen X, Zhu YZ, Sun LY.   +10 more
europepmc   +1 more source