Results 271 to 280 of about 117,111 (323)
The rationale behind targeting the ICOS-ICOS ligand costimulatory pathway in cancer immunotherapy
ESMO Open, 2020 Inducible T cell costimulator (ICOS, cluster of differentiation (CD278)) is an activating costimulatory immune checkpoint expressed on activated T cells. Its ligand, ICOSL is expressed on antigen-presenting cells and somatic cells, including tumour cells
Cinzia Solinas +2 more
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Discovery of ICOS‐Targeted Small Molecules Using Pharmacophore‐Based Screening
ChemMedChem, 2023There are currently no small molecules clinically approved as immune checkpoint modulators. Besides possessing oral bioavailability, cell‐penetrating capabilities and enhanced tumor penetration compared to monoclonal antibodies (mAbs), small molecules ...
Laura Calvo‐Barreiro +5 more
semanticscholar +1 more source
SSRN Electronic Journal, 2020
Freelancing human experts play an important role in Initial Coin Offerings (ICOs). Expert ratings partially reflect the reciprocal network of ICO members and analysts. Ratings predict ICO success, but highly imperfectly so. Favorably rated ICOs tend to fail when more ratings reciprocate prior ratings.
Barth, Andreas +3 more
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Freelancing human experts play an important role in Initial Coin Offerings (ICOs). Expert ratings partially reflect the reciprocal network of ICO members and analysts. Ratings predict ICO success, but highly imperfectly so. Favorably rated ICOs tend to fail when more ratings reciprocate prior ratings.
Barth, Andreas +3 more
openaire +2 more sources
A Theory of ICOs: Diversification, Agency, and Information Asymmetry
Management Sciences, 2020This paper develops a theory of financing of entrepreneurial ventures via crypto tokens, which is not limited to platform-based ventures. We compare token financing with traditional equity financing, focusing on agency problems and information asymmetry ...
J. Chod, Evgeny Lyandres
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Initial Coin Offerings (ICOs) to Finance New Ventures
Journal of Business Venturing, 2018In an initial coin offering (ICO), new ventures raise capital by selling tokens to a crowd of investors. Often, this token is a cryptocurrency, a digital medium of value exchange based on the distributed ledger technology. Both the number of ICOs and the
Christian Fisch
semanticscholar +1 more source
ACM Transactions on Design Automation of Electronic Systems, 1998
The design of multiprocessor architectures differs from uniprocessor systems in that the number of processors and their interconnection must be considered. This leads to an enormous increase in the design-space exploration time, which is exponential in the total number of system components. The methodology proposed here, called
Pao-Ann Hsiung +3 more
openaire +1 more source
The design of multiprocessor architectures differs from uniprocessor systems in that the number of processors and their interconnection must be considered. This leads to an enormous increase in the design-space exploration time, which is exponential in the total number of system components. The methodology proposed here, called
Pao-Ann Hsiung +3 more
openaire +1 more source
ACM Transactions on Computer-Human Interaction, 2009
The design of real-life complex systems calls for advanced software engineering models, methods, and tools in order to meet critical requirements such as reliability, dependability, safety, or resilience that will avoid putting the company, the mission, or even human life at stake.
Navarre, David +3 more
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The design of real-life complex systems calls for advanced software engineering models, methods, and tools in order to meet critical requirements such as reliability, dependability, safety, or resilience that will avoid putting the company, the mission, or even human life at stake.
Navarre, David +3 more
openaire +2 more sources
Initial Coin Offering (ICO) Success and Post-ICO Performance
Management Science, 2022We compile a comprehensive data set of initial coin offerings (ICOs) from 19 data sources including 11 ICO aggregators. We alleviate severe limitations of available ICO data by performing the first systematic analysis of ICO data quality. We use our data set to study determinants of ICO funding success as well as post-ICO operating performance and ...
Evgeny Lyandres +2 more
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Proceedings of the 19th Workshop on Computer Architecture Education, 2017
We present ICOS, a platform for running code on a CPU's "bare metal" (i.e., without a traditional operating system). Our Computer Architecture students use ICOS to carefully time code in order to observe the performance effects of a CPU's branch predictor and superscalar design.
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We present ICOS, a platform for running code on a CPU's "bare metal" (i.e., without a traditional operating system). Our Computer Architecture students use ICOS to carefully time code in order to observe the performance effects of a CPU's branch predictor and superscalar design.
openaire +1 more source
Economics of Innovation and New Technology, 2020
Initial coin offerings (ICOs) are one of the major innovations that characterize the digital revolution of financial markets. Among the expectations created by the digital revolution is the democratization of entrepreneurial finance, defined in terms of ...
Christian Fisch +2 more
semanticscholar +1 more source
Initial coin offerings (ICOs) are one of the major innovations that characterize the digital revolution of financial markets. Among the expectations created by the digital revolution is the democratization of entrepreneurial finance, defined in terms of ...
Christian Fisch +2 more
semanticscholar +1 more source