Results 31 to 40 of about 741 (254)

SIRT1 Prevents Ferroptosis in Corneal Epithelial Cells by Enhancing HIF1α Protein Stability in Dry Eye Disease

Advanced Science, EarlyView.
Hyperosmotic stress drives ferroptosis in corneal epithelium via SIRT1 downregulation. This work demonstrates that SIRT1 activation stabilizes HIF1α, which transcriptionally upregulates GPX4 to inhibit lipid peroxidation and cell death. The identified SIRT1/HIF1α/GPX4 axis reveals a novel defense mechanism and potential therapy for dry eye disease ...
Lili Lian, Zhenmin Le, Xuanqiao Ye, Zimo Wang, Jiuxiao Li, Chenyu Dong, Yetao Shen, Jiazheng Li, Yueping Ren, Xiaoyin Ma, Wei Chen, Qinxiang Zheng   +11 more
wiley   +1 more source

‘Fish in simulated water’? A Bourdieusian analysis of Chinese doctoral students' learning experiences in Southeast Asian developing countries

British Educational Research Journal, EarlyView.
Abstract International student mobility (ISM) has historically followed a pattern of movement from developing regions to developed countries. However, in recent years, there has been a noticeable increase in the number of Chinese students pursuing doctoral studies in Southeast Asian developing countries, an area that has received relatively little ...
Yueyang Zheng, Kun Dai, Alan C. K. Cheung   +2 more
wiley   +1 more source

The impacts of biological invasions

Biological Reviews, EarlyView.
ABSTRACT The Anthropocene is characterised by a continuous human‐mediated reshuffling of the distributions of species globally. Both intentional and unintentional introductions have resulted in numerous species being translocated beyond their native ranges, often leading to their establishment and subsequent spread – a process referred to as biological
Phillip J. Haubrock, Teun Everts, Neil Angelo S. Abreo, Jamie Bojko, Victor Deklerck, James W. E. Dickey, Ana Clara S. Franco, Emili García‐Berthou, Stelios Katsanevakis, Natalia I. Kirichenko, Stefano Mammola, Martin A. Nuñez, Ben Parker, Riccardo Scalera, Ismael Soto, Diederik Strubbe, Ali Serhan Tarkan, Lorenzo Vilizzi, Tim Adriaens, Paride Balzani, Dagmara Błońska, Elizabeta Briski, Rein Brys, Amy L. Burgess, James E. Byers, Carlos Cano‐Barbacil, Giuseppe Castaldelli, Jaimie T.A. Dick, Victoria Dominguez Almela, Romina D. Dimarco, Margarita Florencio, Antonín Kouba, Melina Kourantidou, Irmak Kurtul, Irene Martín‐Forés, Olivier Morissette, Julian D. Olden, Bruno E. Soares, Jakub Truszkowski, Hugo Verreycken, Marc Kenis, Ronaldo Sousa, J. Robert Britton   +42 more
wiley   +1 more source

Formation and Survival of Complex Organic Molecules in the Jovian Circumplanetary Disk

The Planetary Science Journal
Europa, Ganymede, and Callisto are key targets in the search for habitability due to the potential presence of subsurface oceans. Detecting complex organic molecules (COMs), essential for prebiotic chemistry, is crucial to assessing their potential ...
Olivier Mousis, Clément Petetin, Tom Benest Couzinou, Antoine Schneeberger, Yannis Bennacer   +4 more
doaj   +1 more source

Beyond mammals: the evolution of chewing and other forms of oropharyngeal food processing in vertebrates

Biological Reviews, EarlyView.
ABSTRACT Oropharyngeal food processing exhibits a remarkable diversity among vertebrates, reflecting the evolution of specialised ‘processing centres’ associated with the mandibular, hyoid, and branchial arches. Although studies have detailed various food‐processing strategies and mechanisms across vertebrates, a coherent and comprehensive terminology ...
Daniel Schwarz, Maja Mielke, Stephan Handschuh, Anthony Herrel, Patrick Lemell, Léa Da Cunha, Nicolai Konow   +6 more
wiley   +1 more source

When Rare Is Not Small: Amyotrophic Lateral Sclerosis Initiatives and Therapy

Exploration, EarlyView.
In the precision‐medicine era, rare diseases must not be sidelined in translational infrastructure. The Mr. Cai Lei—led “Ice‐Breaking Team” turns an amyotrophic lateral sclerosis patient community into a sustainable ecosystem, realigning philanthropy, data, and research and development to reshape rare‐disease pipelines and guide precision therapies ...
Yang Liu, Xue Xia, Yingfang Chen, Haoying Yang, Xiaochen Chen, Lei Cai, Bingyang Shi   +6 more
wiley   +1 more source

Characterization of Fatty Acid Profiles and Nutritional Quality Indices in Commercial Spreadable Processed Cheeses: Comparative Analysis and Health Implications

Food Safety and Health, EarlyView.
Natural processed cheeses showed a more favorable nutritional profile, including higher unsaturated fatty acids and better functional performance. A balanced fatty acid composition was identified as a key factor influencing meltability, oil separation, and overall quality of processed cheeses.
Shaimaa M. Hamdy, Amr A. Metwally, Mahmoud A. Deghedie, Hani S. Abdelmontaleb   +3 more
wiley   +1 more source

The new meaning of retirement for bridge employees: Situating bridge employment through the lens of the Kaleidoscope Career Model

Human Resource Development Quarterly, Volume 36, Issue 1, Page 89-112, Spring 2025.
Abstract Retirees re‐entering the workforce, popularly termed as bridge employment, is a phenomenon that is anticipated to increase in the coming years. Though research establishes that these employees have unique aspirations and work motives (see Mazumdar et al., 2020), primary research on how the retirement transition and bridge employment shape each
Bishakha Mazumdar, Amy M. Warren, Travor C. Brown   +2 more
wiley   +1 more source

Large Proportions of Surface Ozone and Premature Mortality Due to a Stratospheric Intrusion Event in North China

International Journal of Climatology, EarlyView.
This study, by examining a typical stratospheric intrusion event that occurred in North China from 30 to 31 July 2021, found that the event led to a sharp increase in near‐surface ozone concentrations by 23 ppbv within 36 h, accounting for 40% of the total observed ozone levels, with localised peaks exceeding 30 ppbv.
Yinghan Sun, Zhicong Yin, Yijia Zhang
wiley   +1 more source

Timing and Abundance of Clathrate Formation Control Ocean Evolution in Outer Solar System Bodies: Challenges of Maintaining a Thick Ocean within Pluto

The Planetary Science Journal, 2023
Clathrate hydrates may represent a sizable fraction of material within the icy shells of Kuiper Belt objects and icy moons. They influence the chemical and thermal evolution of subsurface oceans by locking volatiles into the ice shell and by providing ...
Samuel W. Courville, Julie C. Castillo-Rogez, Mohit Melwani Daswani, Elodie Gloesener, Mathieu Choukroun, Joseph G. O’Rourke   +5 more
doaj   +1 more source