Results 1 to 10 of about 49,333 (314)

SMYD2 epigenetically activates BMP4/SMAD1/5/8/ID3 axis to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma [PDF]

Neoplasia: An International Journal for Oncology Research
Background: Drug resistance prominently hampers the effects of sorafenib in hepatocellular carcinoma (HCC). Epigenetics play important roles in drug resistance.
Shanshan Wang, Weicheng Wu, Zhen Shi, Mei Bin, Fengwei Zhang, Long Cai, Kaiqing Lin, Zhihui Li   +7 more
doaj   +3 more sources

A positive feedback loop between ID3 and PPARγ via DNA damage repair regulates the efficacy of radiotherapy for rectal cancer

BMC Cancer, 2023
Objective To study the effect of inhibitor of differentiation 3 (ID3) on radiotherapy in patients with rectal cancer and to explore its primary mechanism.
Chuanzhong Huang, Ling Wang, Huijing Chen, Wankai Fu, Lingdong Shao, Dongmei Zhou, Junxin Wu, Yunbin Ye   +7 more
doaj   +2 more sources

Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1–mediated immune suppression during GVHD [PDF]

Blood, 2023
Persisting alloreactive donor T cells in target tissues are a determinant of graft-versus-host disease (GVHD), but the transcriptional regulators that control the persistence and function of tissue-infiltrating T cells remain elusive. We demonstrate here
Ying Wang, Shan He, Gennaro Calendo, Tien D. Bui, Yuanyuan Tian, Che Young Lee, Yan Zhou, Xin Zhao, Ciril Abraham, Wenbin Mo, Mimi Chen, Ruqayyah sanders-Braggs, Jozef Madžo, Jean‐Pierre J. Issa, Elizabeth O. Hexner, David L. Wiest, Ran Reshef, Hai‐Hui Xue, Yi Zhang   +18 more
openalex   +2 more sources

Id3 expression identifies CD4 ⁺ memory Th1 cells

Proceedings of the National Academy of Sciences, 2022
Memory CD4 + T cells play a pivotal role in mediating long-term protective immunity, positioning them as an important target in vaccine development. However, multiple functionally distinct helper CD4 + T-cell subsets can arise in response to a single invading pathogen, complicating the ...
Laura A. Shaw, Tianda Z. Deng, Kyla D. Omilusik, Kennidy K. Takehara, Quynh P. Nguyen, Ananda W. Goldrath   +5 more
openaire   +3 more sources

Loss of ID3 drives papillary thyroid cancer metastasis by targeting E47-mediated epithelial to mesenchymal transition

Cell Death Discovery, 2021
Papillary thyroid cancer (PTC) is the main histological type of thyroid cancer and accounts for almost all increased cases worldwide. Patients with PTC exhibit a favorable prognosis, but the fact that PTC is often accompanied by a high prevalence of ...
Sunwang Xu, Caiqin Mo, Junyu Lin, Yixing Yan, Xiaoyu Liu, Kunlin Wu, Huihao Zhang, Youzhi Zhu, Ling Chen, Xiangjin Chen   +9 more
doaj   +2 more sources

Shifting gears: Id3 enables recruitment of E proteins to new targets during T cell development and differentiation

Frontiers in Immunology, 2022
Shifting levels of E proteins and Id factors are pivotal in T cell commitment and differentiation, both in the thymus and in the periphery. Id2 and Id3 are two different factors that prevent E proteins from binding to their target gene cis-regulatory ...
Michele K. Anderson, Michele K. Anderson
doaj   +2 more sources

Research on hybrid intrusion detection method based on the ADASYN and ID3 algorithms

Mathematical Biosciences and Engineering, 2022
Intrusion detection system plays an important role in network security. Early detection of the potential attacks can prevent the further network intrusion from adversaries. To improve the effectiveness of the intrusion detection rate, this paper proposes
Yue Li , Wusheng Xu, Wei Li , Ang Li, Zengjin Liu   +4 more
doaj   +2 more sources

Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression. [PDF]

Sci Immunol
Stem-like T cells are attractive immunotherapeutic targets in patients with cancer given their ability to proliferate and differentiate into effector progeny.
Gago da Graça C, Sheikh AA, Newman DM, Wen L, Li S, Shen J, Zhang Y, Gabriel SS, Chisanga D, Seow J, Poch A, Rausch L, Nguyen MT, Singh J, Su CH, Cluse LA, Tsui C, Burn TN, Park SL, Von Scheidt B, Mackay LK, Vasanthakumar A, Bending D, Shi W, Cui W, Schröder J, Johnstone RW, Kallies A, Utzschneider DT.   +28 more
europepmc   +2 more sources

CD5L promotes M2 macrophage polarization through autophagy-mediated upregulation of ID3 [PDF]

Frontiers in Immunology, 2018
CD5L (CD5 molecule-like) is a secreted glycoprotein that controls key mechanisms in inflammatory responses, with involvement in processes such as infection, atherosclerosis, and cancer.
Amézaga, Núria, Aran, Gemma, Armengol, Carolina, López Codina, Daniel, Prats Soler, Clara, Sanjurjo, Lucía, Sarrias, Maria Rosa, Téllez, Érica   +7 more
core   +3 more sources

ID1/ID3 mediate the contribution of skin fibroblasts to local nerve regeneration through Itga6 in wound repair

Stem Cells Translational Medicine, 2021
Cutaneous wound healing requires intricate synchronization of several key processes. Among them, local nerve regeneration is known to be vitally important for proper repair. However, the underlying mechanisms of local nerve regeneration are still unclear.
Zelin Chen, Gufang Shen, Xu Tan, Langfan Qu, Can Zhang, Le Ma, Peng Luo, Xiaohui Cao, Fan Yang, Yunsheng Liu, Yu Wang, Chunmeng Shi   +11 more
doaj   +2 more sources