Results 51 to 60 of about 49,333 (314)

Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells [PDF]

, 2018
Wiring metabolic signaling circuits in thymocytes Cell differentiation is often accompanied by metabolic changes. Yang et al. report that generation of double-positive (DP) thymocytes from double-negative (DN) cells coincides with dynamic regulation of ...
Awad, Walid, Blanco, Daniel Bastardo, Chen, Wenan, Chen, Xiang, Cheng, Changde, Chi, Hongbo, Dash, Pradyot, Dhungana, Yogesh, Easton, John, Guo, Xi-Zhi J., Kc, Anil, Neale, Geoffrey, Rosencrance, Celeste, Thomas, Paul G., Yang, Kai   +14 more
core   +1 more source

Id3 Orchestrates Germinal Center B Cell Development [PDF]

Molecular and Cellular Biology, 2016
Previous studies have demonstrated that E proteins induce activation-induced deaminase (AID) expression in activated B cells. Here, we examined the role of Id3 in germinal center (GC) cells. We found that Id3 expression is high in follicular B lineage cells but declines in GC cells.
Shuwen, Chen, Masaki, Miyazaki, Vivek, Chandra, Kathleen M, Fisch, Aaron N, Chang, Cornelis, Murre   +5 more
openaire   +2 more sources

Low-lying continuum states of drip-line Oxygen isotopes [PDF]

, 2015
Low-lying continuum states of exotic oxygen isotopes are studied, by introducing the Continuum-Coupled Shell Model (CCSM) characterized by an infinite wall placed very far and by an interaction for continuum coupling constructed in a close relation to ...
Fujimoto, Rintaro, Otsuka, Takaharu, Tsukiyama, Koshiroh   +2 more
core   +1 more source

EDT-STACK: A stacking ensemble-based decision trees algorithm for tire tread depth condition classification

Results in Engineering
Tires serve as the critical interface between a vehicle and the road. Their condition significantly impacts road safety, vehicle performance, fuel efficiency, and operational costs.
Mostafizur Rahman, Noorfazila Kamal, Nor Fadzilah Abdullah   +2 more
doaj   +1 more source

BMP4 Exerts Anti-Neurogenic Effect via Inducing Id3 during Aging

Biomedicines, 2022
Bone morphogenetic protein (BMP) signaling has been shown to be intimately associated with adult neurogenesis in the subventricular zone (SVZ) and subgranular zone (SGZ). Adult neurogenesis declines in aging rodents and primates. However, the role of BMP
Tingting Li, Hongmei Liu, Dongfang Jiang, Keyan Yang, Jiaqi Shen, Haiping Feng, Sijia Wang, Yuxin Zhang, Yun Wang, Tie-Shan Tang   +9 more
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Id1 and Id3 co-expression correlates with clinical outcome in stage III-N2 non-small cell lung cancer patients treated with definitive chemoradiotherapy

Journal of Translational Medicine, 2013
Background Inhibitor of DNA binding 1 (Id1) and 3 (Id3) genes have been related with the inhibition of cell differentiation, cell growth promotion and tumor metastasis.
Castañon Eduardo, Bosch-Barrera Joaquim, López Inés, Collado Víctor, Moreno Marta, López-Picazo José María, Arbea Leire, Lozano María Dolores, Calvo Alfonso, Gil-Bazo Ignacio   +9 more
doaj   +1 more source

The nuclear factor ID3 endows macrophages with a potent anti-tumour activity

Nature
Macrophage activation is controlled by a balance between activating and inhibitory receptors1–7, which protect normal tissues from excessive damage during infection8,9 but promote tumour growth and metastasis in cancer7,10.
Zihou Deng, Pierre-Louis Loyher, T. Lazarov, Li Li, Zeyang Shen, B. Bhinder, Hairu Yang, Yi Zhong, Araitz Alberdi, J. Massagué, Joseph C. Sun, R. Benezra, C. K. Glass, O. Elemento, Christine A. Iacobuzio-Donahue, F. Geissmann   +15 more
semanticscholar   +1 more source

Adipocyte progenitor cells initiate monocyte chemoattractant protein-1-mediated macrophage accumulation in visceral adipose tissue

Molecular Metabolism, 2015
Objective: Macrophages are important producers of obesity-induced MCP-1; however, initial obesity-induced increases in MCP-1 production precede M1 macrophage accumulation in visceral adipose tissue (VAT).
Jennifer L. Kaplan, Melissa A. Marshall, Chantel C. McSkimming, Daniel B. Harmon, James C. Garmey, Stephanie N. Oldham, Peter Hallowell, Coleen A. McNamara   +7 more
doaj   +1 more source

A survey of cost-sensitive decision tree induction algorithms [PDF]

, 2013
The past decade has seen a significant interest on the problem of inducing decision trees that take account of costs of misclassification and costs of acquiring the features used for decision making.
Bradford J. P., Elkan C., Esmeir S., Esmeir S., Estruch V., Fan W., Ferri C., Freund Y., Hart A. E., Knoll U., Li J., Lin F. Y., Liu X., Mease D., Murthy S., Ni A., Norton S. W., Pazzani M., Quinlan J. R., Quinlan J. R., Schapire R. E., Sunil Vadera, Susan Lomax, Swets J., Tan M., Ting K., Ting K., Ting K. M., von Neumann J., Zadrozny B.   +29 more
core   +2 more sources