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open access: yes
Geophysical Research Letters, Volume 53, Issue 6, 28 March 2026.
Kristopher Karnauskas   +40 more
wiley   +1 more source

Extramedullary Disease—Achilles Heel in Myeloma?

open access: yesAmerican Journal of Hematology, Volume 101, Issue 3, Page 521-536, March 2026.
ABSTRACT Despite advances in therapy, extramedullary disease (EMD) remains an aggressive form of multiple myeloma associated with poor outcomes. Patients with true EMD, in which plasmacytomas have become completely independent of bone, have a particularly poor prognosis. The pathogenesis of EMD is driven by complex mechanisms involving loss of adhesion
Shaji Kumar   +7 more
wiley   +1 more source

Granulomatosis With Polyangiitis Presenting as Deep Vein Thrombosis in an Adolescent: A Rare Case Report

open access: yesClinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Granulomatosis with polyangiitis can rarely present as deep vein thrombosis in adolescents. Unexplained thrombosis in a young patient, accompanied by systemic inflammatory features, should raise suspicion for an underlying vasculitis. Early recognition and prompt initiation of immunosuppressive therapy alongside anticoagulation are crucial to ...
Bishal Budha   +8 more
wiley   +1 more source

Rapamycin Reduces Amyloid‐β Plaques and Improves Behavioral Performance in a Sex‐Dependent Manner in Mouse Models of Amyloidosis

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Rapamycin treatment reduced cerebral Aβ plaque burden, alleviated neuritic dystrophy, suppressed glial hyperactivation, and increased plaque‐associated microglial recruitment in amyloidosis mouse models, resulting in improved memory performance. Mechanistically, rapamycin enhanced microglial lysosomal degradation, facilitated lipid droplet clearance in
Shihui Guo   +6 more
wiley   +1 more source

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