Results 71 to 80 of about 56,938 (262)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Congenital melanocytic nevi management: question

Journal of Pediatric and Neonatal Individualized Medicine, 2016
A 12-year-old girl presented to our attention for a pigmented lesion having greatest diameter of 2.5 cm, located on her left forehead, involving the ipsilateral eyebrow. This lesion had appeared as a flat brown macule at birth.
Stefania Guida, Giacomo Giovanni Urtis, Giuseppe Rubino, Giovanni Pellacani, Francesca Farnetani   +4 more
doaj   +1 more source

Host Cell Protein Challenges in Antibody Processing: Insights Into Persistence and Mitigation Strategies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh, Andrew Cooke, Harshal Soni, Susan Liu, Mamadou Bah, Brianna Bellis, Laura Smith, Michael Capaldi, Nicholas Levy, Erik Wilhelm, Kristopher Barnthouse   +10 more
wiley   +1 more source

Circular Economy in Crisis Contexts: An Assessment Framework for Post‐Disaster Building Stock Toward Strategic Autonomy

Business Strategy and the Environment, EarlyView.
ABSTRACT Post‐disaster contexts generate large volumes of damaged building stock with significant, yet often unquantified, circularity potential. Through the lens of strategic management, the circular economy emerges as a transformative pathway to strengthen systemic resilience by reducing dependencies on external resources and mitigating supply chain ...
Tetiana Shevchenko, Julian Kirchherr, Meisam Ranjbari, Bernard Yannou, Michael Saidani   +4 more
wiley   +1 more source

Redes Neuronales Artificiales: factores que determinan la cosecha de caña en la industria azucarera

Ciencia UNEMI, 2019
La investigación muestra lo importante de las redes neuronales artificiales dentro de la industria azucarera, como una herramienta útil para la predicción del cultivo de la caña de azúcar, tomando como entradas la información climatológica: temperaturas ...
Ítalo Mendoza Haro, Hiram Marquetti Nodarse   +1 more
doaj  

Model‐Based Analysis with Mechanistic Insights to CAR‐T‐Cell Therapy Kinetics: Case Study with Axicabtagene Ciloleucel and Brexucabtagene Autoleucel

Clinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development is increasingly used to support chimeric antigen receptor (CAR)‐T‐cell therapy programs. However, most population pharmacokinetic (PK) CAR‐T‐cell models available in literature are variations of an empirical piecewise‐linear model, which accurately describes the observed data but lacks a mechanistic foundation.
Anna M. Mc Laughlin, Martin Bergstrand, Ana Ruiz‐Garcia, Simone Filosto, Rhine Shen   +4 more
wiley   +1 more source

IDE-IDE PEMBAHARUAN FAZLUR RAHMAN

ALQALAM, 1997
Ide-Ide Pembaharuan Fazlur ...
openaire   +2 more sources

CSR Disclosure and Operating Performance in the Agri‐Food Manufacturing Industry: Evidence From Southern Europe

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study explores the relationship between corporate social responsibility (CSR) disclosure and operating profitability in the agri‐food manufacturing industry of Southern Europe, focusing on Extremadura (Spain). From an initial pool of 284 firms, the final sample comprised 185 companies after excluding inactive or non‐reporting cases.
Ángel Sabino Mirón Sanguino, Maria Pache Durán, Triana Arias Abelaira, María Beatriz Corchuelo Mártinez Azua   +3 more
wiley   +1 more source

INNOVATION PROCESS OF NATURAL-RESOURCE-BASED FIRMS IN FOUR ASEAN ECONOMIES: AN SEM APPROACH

STIPM (STI Policy and Management) Journal, 2017
This paper focuses on natural-resource-based firms in four ASEAN economies, such as Vietnam, Indonesia, The Philippines, and Thailand. These countries have relative advantage in natural-resource-based industries, since they have affluent endowed ...
Masatsugu Tsuji, Hiroki Idota, Yasushi Ueki, Teruyuki Bunno   +3 more
doaj   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source