Results 51 to 60 of about 5,861,579 (291)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

You reap what you sow: knowledge hiding, territorial and idea implementation

, 2020
This study aims to build a research model from the perspectives of knowledge hiding and idea implementation to examine what factors influence idea implementation and the cross-level moderating role of team territory climate.https://macewan.primo ...
Huo, Weiwei, Zheng, Manyi, Wei, William Xiaojun, Huang, Yi, Yan, Jinyi, Li, Xianmiao   +5 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Employee innovation: The roles of idea generation and idea implementation [PDF]

, 2000
This study tested the hypothesis that motivation, job competence and creative personality indirectly influenced innovation via idea generation. Results showed that the effects of creative personality and motivation on innovation were, indeed, mediated ...
Unsworth, Kerrie L., McGuire, Lauren, Brown, Hilary   +2 more
core  

Eliciting group judgements about replicability: a technical implementation of the IDEA Protocol

, 2020
Appendicies for the paper: Eliciting group judgements about replicability: a technical implementation of the IDEA ...
Ross Pearson
core   +3 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

The impact of perceived environmental corporate social responsibility on idea generation and idea implementation

Humanities & Social Sciences Communications
Scholars have already made a few outcomes regarding the effect of environmental corporate social responsibility (ECSR) on employees’ workplace behaviors.
Li Yu, Weiwei Wu
doaj   +1 more source

Universal basic income: idea, concept, characteristics of the practical implementation

Государственное и муниципальное управление: Учёные записки
Universal basic income has emerged as a novel socio-economic concept in response to major social crises, periods of high unemployment, and the COVID-19 pandemic, stimulating considerable interest among academic and policy circles worldwide.
L. S. Skachkova, Xiaran Zhang
doaj   +1 more source

Design and implementation of an ASIP-based cryptography processor for AES, IDEA, and MD5

Engineering Science and Technology, an International Journal, 2017
In this paper, a new 32-bit ASIP-based crypto processor for AES, IDEA, and MD5 is designed. The instruction-set consists of both general purpose and specific instructions for the above cryptographic algorithms. The proposed architecture has nine function
Karim Shahbazi, Mohammad Eshghi, Reza Faghih Mirzaee   +2 more
doaj   +1 more source