Results 71 to 80 of about 114,639 (262)
How to Change the Travellers' Mobility Behaviours? - Examples of Mobility Plans
Communications, 2009 The paper presents a mobility management concept as well as gives examples of mobility plans which are fundamental instruments of mobility management.
Katarzyna Nosal
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FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
BREAST MILK THAT WE DID NOT KNOW: CHRONOBIOLOGY OF BREAST MILK
Вопросы современной педиатрии, 2018 The article analyzes modern scientific data on the changes in breast milk composition during lactation. These changes affect both short-term (sleep, appetite) and long-term parameters (growth and development, temperament, behavior) with respect to the ...
Sergey E. Ukraintsev, Tatyana N. Samal
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
RUDN Journal of Political ScienceDue to the increasing influence of the People’s Republic of China in world politics against the background of the transformation of the global world order, the concept of the “Community of the Common Destiny for Mankind”, which defines the main vector of
Jingyuan Liu
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Tourism promotion and urban space in Barcelona. Historic perspective and critical review, 1900-1936
Documents d'Anàlisi Geogràfica, 2015 This paper focuses on the historic connections between tourist promotion as a factor for both capital attraction and competitiveness and its influence on the urban configuration of Barcelona.
Agustín Cócola Gant, Saida Palou Rubio
doaj
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source