Results 131 to 140 of about 7,408,822 (366)

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

open access: yesFEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian   +6 more
wiley   +1 more source

Practical challenges in data‐driven interpolation: Dealing with noise, enforcing stability, and computing realizations

open access: yesInternational Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley   +1 more source

Unique factorization of ideals into nonfactorable ideals [PDF]

open access: yesProceedings of the American Mathematical Society, 1964
The purpose of this note is to prove a theorem which shows a connection between the definition of a prime ideal in classical algebraic number theory and the usual definition of a prime ideal. A proper ideal in an integral domain with unit element is an ideal different from the unit ideal and the zero ideal.
openaire   +3 more sources

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

open access: yesFEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda   +9 more
wiley   +1 more source

Data‐driven performance metrics for neural network learning

open access: yesInternational Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri   +2 more
wiley   +1 more source

Geoengineering and Non-Ideal Theory [PDF]

open access: yes, 2016
The strongest arguments for the permissibility of geoengineering (also known as climate engineering) rely implicitly on non-ideal theory—roughly, the theory of justice as applied to situations of partial compliance with principles of ideal justice. In an
Morrow, David R., Svoboda, Toby
core  

T-Ideals and C-Ideals [PDF]

open access: yesProceedings of the Edinburgh Mathematical Society, 1979
Given a ring R we consider the category Ŕ of R-rings (rings A with given ring-homomorphisms R → A), and R-homomorphisms (ring-homomorphisms that form commutative triangles with the given maps from R). All rings are associative and have 1, all homomorphisms send 1 to 1.We define a c-R-ring as an object A in Ŕ with a family of maps {ρx ∈ homŔ(A,A)|x∈A ...
openaire   +2 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

ON ℐ^𝒦-CONVERGENCE OF SEQUENCES OF BI-COMPLEX NUMBERS

open access: yesПроблемы анализа
We propose the concept of ℐ^𝒦-convergence of sequences of bi-complex numbers. We explore the fundamental properties of this newly introduced notion and its relationships with other convergence ...
J. Hossain, S. Debnath
doaj   +1 more source

Approaching the ideal elastic strain limit in silicon nanowires

open access: yesScience Advances, 2016
Single-crystalline silicon nanowires can be reversibly stretched above 10% elastic strain at room temperature. Achieving high elasticity for silicon (Si) nanowires, one of the most important and versatile building blocks in nanoelectronics, would enable ...
Hongti Zhang   +10 more
semanticscholar   +1 more source

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