Results 171 to 180 of about 35,855 (292)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

open access: yesAdvanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi   +13 more
wiley   +1 more source

Scalable HMO-CNN-SVM Framework for Skin Lesion Classification: A Metaheuristic-Driven Approach With Parallelizable Optimization for Cluster Deployment. [PDF]

open access: yesBiomed Eng Comput Biol
Fendzi Mbasso W   +6 more
europepmc   +1 more source

On statistical measure theory

open access: yes, 2013
Natural Science Foundation of China [11071021]The purpose of this paper is to unify various kinds of statistital convergence by statistical measure convergence and to present Jordan decomposition of finitely additive measures.
Bao, Lingxin, 程立新, Cheng, Lixin
core  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu   +4 more
wiley   +1 more source

Miniaturized Bidirectional Thermal Stimulation System Integrated With an Electrode Array for Recording Neural Activities

open access: yesAdvanced Science, EarlyView.
This study presents a miniaturized bidirectional thermal stimulation system integrated with an electrode array enabling real‐time, bidirectional modulation and simultaneous recording of neural activity through localized heating and cooling. By monolithic integration of the Peltier element and with a silicon neural probe, the innovative system allows ...
Zoia Naumkina   +6 more
wiley   +1 more source

Combining Fret and Super‐Resolution Microscopy Reveals Kinase Activation and Mitochondrial Activity at the Nanoscale

open access: yesAdvanced Science, EarlyView.
BioSenSRRF is an open‐source workflow that combines conventional FRET biosensors with SRRF reconstruction to generate sub‐diffraction FRET index maps on standard microscopes. The pipeline integrates automated image registration, SRRF reconstruction, quantitative FRET index calculation, and random line‐based hotspot analysis to uncover AURKA‐dependent ...
Nicolas Y. Jolivet   +5 more
wiley   +1 more source

ON IDEAL CONVERGENCE OF DOUBLE SEQUENCES IN NEUTROSOPHIC FUZZY G-METRIC SPACES

open access: yes
The primary aim of this article is to introduce the concept of ideal convergence for double sequences in neutrosophic fuzzy G-metric spaces (NFGMS) with order q.
Khan, Vakeel Ahmad   +2 more
core  

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