Results 141 to 150 of about 1,112,610 (386)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Hypertrophic cardiomyopathy in identical twins: a case series. [PDF]

open access: yesEur Heart J Case Rep, 2023
Ashraf M   +5 more
europepmc   +1 more source

The arrow of time: from universe time-asymmetry to local irreversible processes

open access: yes, 2007
In several previous papers we have argued for a global and non-entropic approach to the problem of the arrow of time, according to which the ''arrow'' is only a metaphorical way of expressing the geometrical time-asymmetry of the universe.
A. Bohm   +48 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Transcriptional Differences in Identical Twins With Different Reproductive Capacities: A Case Report. [PDF]

open access: yesCureus, 2023
Campbell K   +8 more
europepmc   +1 more source

Income, Schooling, and Ability: Evidence from a New Sample of Identical Twins [PDF]

open access: yes
We develop a model of optimal schooling investments and estimate it using new data on approximately 700 identical twins. We estimate an average return to schooling of 9 percent for identical twins, but estimated returns appear to be slightly higher for ...
Cecilia Rouse, Orley Ashenfelter
core  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

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