VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
On the structural identifiability of nonlinear models of ligand binding dynamics. [PDF]
J Pharmacokinet PharmacodynWhite C, Rottschäfer V, Bridge L.
europepmc +1 more source
Advanced Science, EarlyView.This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang +10 more
wiley +1 more source
I-GraphECG: Observability-Based Lead Selection and Interpretable Disease Prediction from the 12-Lead ECG Using a Gray-Box Graph Electrophysiology Surrogate. [PDF]
Sensors (Basel)Zhao L, Xu H, Wang P, Fu W, Zhang N.
europepmc +1 more source
Advanced Science, EarlyView.In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun +15 more
wiley +1 more source
From Biological Mechanisms to Causal Inference: Quantitative Systems Pharmacology and Causal Frameworks in Drug Development. [PDF]
Clin Pharmacol TherKlabunde T +3 more
europepmc +1 more source
Monitoring Parameter Identifiability With AUDI
, 1994 A simple, practical and unified method is presented for detecting the parameter identifiability problems due to non-persistent excitation, overparameterization and/or output feedback within the identified system. All the required information is generated
Steve Niu, Niu, Steve
core
F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling
Advanced Science, EarlyView.ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao +9 more
wiley +1 more source
Post-MI Remodeling Mechanics of Left Ventricle: Microstructure-Informed Models, Identifiability, and Uncertainty for Patient-Specific Prediction. [PDF]
Bioengineering (Basel)Pandelani T, Nemavhola F.
europepmc +1 more source
An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli
Advanced Science, EarlyView.An innervated human skin equivalent is integrated with high‐density microelectrode arrays to reveal how engineered free nerve ending–like structures translate touch and temperature into electrical codes. Mechanical indentation and thermal stimulation engage the engineered somatosensory circuitry and evoke distinct firing and waveform signatures ...
Daniele Bellantoni +6 more
wiley +1 more source