Results 151 to 160 of about 13,723,248 (323)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Identification of a novel Parkinson’s disease locus via stratified genome-wide association study [PDF]

, 2014
Erin M. Hill‐Burns, William T. Wissemann, Taye H. Hamza, Stewart A. Factor, Cyrus P. Zabetian, Haydeh Payami   +5 more
openalex   +1 more source

miR-29b-3p regulates cardiomyocytes pyroptosis in CVB3-induced myocarditis through targeting DNMT3A

Cellular & Molecular Biology Letters
Background Viral myocarditis (VMC) is a disease resulting from viral infection, which manifests as inflammation of myocardial cells. Until now, the treatment of VMC is still a great challenge for clinicians.
Ya Wang, Zhengyang Zhang, Hui Li, Min Wang, Yuting Qiu, Lili Lu   +5 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Representation and identification of activity cliffs [PDF]

, 2017
Jürgen Bajorath
openalex   +1 more source

Navigating change in the era of COVID-19: The role of top leaders’ charismatic rhetoric and employees’ organizational identification

, 2021
Cen April Yue
openalex   +2 more sources

Butyric acid and valeric acid attenuate stress-induced ferroptosis and depressive-like behaviors by suppressing hippocampal neuroinflammation

Journal of Translational Medicine
Background Depression is closely associated with stress-induced hippocampal damage and dysfunction. Emerging evidence demonstrates that the gut microbiota and its metabolites, acting as probiotics or prebiotics, can modulate brain structure and function ...
Xiaoying Ma, Weibo Shi, Zhen Wang, Shujin Li, Rufei Ma, Weihao Zhu, Lin Wu, Xiaowei Feng, Bin Cong, Yingmin Li   +9 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Validating task analysis for error identification: reliability and validity of a human error prediction technique [PDF]

, 2005
Neville A. Stanton, Chris Baber
openalex   +1 more source

Designing a Fruit Identification Algorithm in Orchard Conditions to Develop Robots Using Video Processing and Majority Voting Based on Hybrid Artificial Neural Network [PDF]

, 2020
Sajad Sabzi, Razieh Pourdarbani, Davood Kalantari, Τhomas Panagopoulos   +3 more
openalex   +1 more source