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Identification and biology of β‐secretase [PDF]
J. Neurochem. (2012) 120 (Suppl. 1), 55–61.AbstractOur knowledge of the etiology of Alzheimer’s disease (AD) has advanced tremendously since the discovery of amyloid beta (Aβ) aggregation in diseased brains. Accumulating evidence suggests that Aβ plays a causative role in AD.
Patty C. Kandalepas, Robert Vassar
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Identification of Structural Domains Involved in Astrovirus Capsid Biology [PDF]
Coat proteins of non-enveloped, icosahedral viruses must perform a variety of functions during their life cycle such as assembly of the coat protein subunits into a closed shell, specific encapsidation of the viral nucleic acid, maturation of the capsid, interaction with host receptors, and disassembly to deliver the genetic information into the newly ...
Neel K. Krishna
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Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach [PDF]
Axon guidance is a crucial process for growth of the central and peripheral nervous systems. In this study, 3 axon guidance related disorders, namely- Duane Retraction Syndrome (DRS) , Horizontal Gaze Palsy with Progressive Scoliosis (HGPPS) and Congenital fibrosis of the extraocular muscles type 3 (CFEOM3) were studied using various Systems Biology ...
Ishtiaque Ahammad
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Target Identification Strategies in Plant Chemical Biology [PDF]
The current needs to understand gene function in plant biology increasingly require more dynamic and conditional approaches opposed to classic genetic strategies.
Wim eDejonghe+3 more
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Networks in Biology – From Identification, Analysis to Interpretation [PDF]
Over the last decade networks has become a unifying language in biology. Yet we are only in the beginning of understanding their significance for biology and their medical applications. I will talk about the diversity of biological networks composed either of genes, proteins, metabolites, or cells and the associated methods for finding these graphs in ...
Jesper Tegnér
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SYSTEM IDENTIFICATION CHALLENGES FROM SYSTEMS BIOLOGY
Abstract Systems biology is the understanding through computational modelling of the function of biological systems. New high-throughput experimental technologies can measure simultaneously the levels of expression of thousands of genes. The challenge is to extract knowledge from these data sets in order to understand the regulatory machinery of the ...
Edmund J. Crampin
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Molecular Identification of Trypanosoma theileri and Biology of Trypanosomes
Trypanosoma theileri (T. theileri ) is a non-pathogenic, cosmopolitan, and commensal protozoa of cattle. The main objective of the current study was to investigate the biology and feasibility of T. theileri as a model candidate for the discovery of a novel drug. In the present study, the isolates of T.
Tewodros Fentahun, Jan Paeshuyse
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Hospital-acquired infections (HAIs) pose a serious threat to patients, and hospitals spend billions of dollars each year to reduce and treat these infections.
Jeremy Chen See+17 more
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Anatomical Injection Guidelines for Glabellar Frown Lines Based on Ultrasonographic Evaluation
When botulinum neurotoxin (BoNT) is injected to treat glabellar frown lines, the corrugator supercilia muscle (CSM) and procerus muscles are the main targets.
Soo-Bin Kim+6 more
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Analysis of facial ultrasonography images based on deep learning
Transfer learning using a pre-trained model with the ImageNet database is frequently used when obtaining large datasets in the medical imaging field is challenging.
Kang-Woo Lee+3 more
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