Results 191 to 200 of about 2,273,623 (352)

Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy [PDF]

, 2018
Lin Cao, Jizheng Chen, Yaxin Wang, Yuting Yang, Jie Qing, Zihe Rao, Xinwen Chen, Zhiyong Lou   +7 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Macrobenthic communities of the continental shelf of Heraklion Bay (Crete, Greece): bathymetric distribution and temporal trends. [PDF]

Biodivers Data J
Koumpaki E, Maidanou M, Chatzigeorgiou G, Rallis I, Mavraki D, Dounas C, Arvanitidis C, Koulouri P.   +7 more
europepmc   +1 more source

Identification and Biology of Common Caterpillars in U.S. Soybean

, 2021
Erin W. Hodgson, Robert L. Koch, Jeffrey A. Davis, Dominic Reisig, Silvana V. Paula‐Moraes   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Identification of Key Proteins Involved in Axon Guidance Related Disorders: A Systems Biology Approach

, 2018
Ishtiaque Ahammad
openalex   +3 more sources

Rapid on-site universal vertebrate species identification via multi-barcode nanopore sequencing. [PDF]

PLoS One
Patterson EC, Morrison-Lanjouw S, Jobling MA, Wetton JH.   +3 more
europepmc   +1 more source

Identification of abiotic and biotic reductive dechlorination in a chlorinated ethene plume after thermal source remediation by means of isotopic and molecular biology tools

, 2016
Alice Badin, Mette Martina Broholm, Carsten Suhr Jacobsen, Jordi Palau, Philip Dennis, Daniel Hunkeler   +5 more
openalex   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Identification and Analysis of Key lncRNAs for Adipose Differentiation. [PDF]

Biology (Basel)
Xie X, Li T, Zhang B, Liao J, Zhang X, Gao J, Cheng X, Meng T, Xu Y, Zhang P, Li C.   +10 more
europepmc   +1 more source