Results 321 to 330 of about 5,701,500 (381)

Identification of parameters in systems biology

Mathematical Biosciences, 2018
We consider the inverse problem for the identification of the finite dimensional set of parameters for systems of nonlinear ordinary differential equations (ODEs) arising in systems biology. A numerical method which combines Bellman's quasilinearization with sensitivity analysis and Tikhonov's regularization is implemented.
Ugur G. Abdulla, Roby Poteau
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Identification and biology of α‐secretase

Journal of Neurochemistry, 2011
J. Neurochem.(2012)120(Suppl. 1), 34–45.Absract‘Secretase’ is a generic term coined more than 20 years ago to refer to a group of proteases responsible for the cleavage of a vast number of membrane proteins. These endoproteolytic events result in the extracellular or intracellular release of soluble metabolites associated with a broad range of ...
Valérie Vingtdeux, Philippe Marambaud
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DWARF BUNT: Politics, Identification, and Biology [PDF]

Annual Review of Phytopathology, 1996
▪ Abstract  Dwarf bunt is a disease of wheat caused by the smut fungus Tilletia controversa Kuhn. Winter wheat (Triticum aestivum L.) is the primary host of economic significance. Although the total acreage affected by dwarf bunt is small relative to total wheat production worldwide, the disease has assumed attention disproportionate to its economic ...
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Nanopore-Based Protein Identification.

Journal of the American Chemical Society, 2022
The implementation of a reliable, rapid, inexpensive, and simple method for whole-proteome identification would greatly benefit cell biology research and clinical medicine.
Mazdak Afshar Bakshloo, J. Kasianowicz, Manuela Pastoriza-Gallego, J. Mathé, R. Daniel, F. Piguet, A. Oukhaled   +6 more
semanticscholar   +1 more source

Recent Advances in the System Biology-based Target Identification and Drug Discovery.

Current Topics in Medicinal Chemistry, 2018
The enormous quantity of publicly available active chemical ligand and biological receptor data knowledge allows scientists to retreat several open questions by the analysis and systematic integration of these complex unique data. Systems biology plays a
Brijesh Singh Yadav, Vijay Tripathi
semanticscholar   +1 more source

Drug target identification through systems biology

Drug Discovery Today: Technologies, 2015
To rationalise drug target selection, we should understand the role of putative targets in biological pathways quantitatively. We review here how experimental and computational network-based approaches can aid more rational drug target selection and illustrate this with results obtained for microbes and for cancer.
Barbara M. Bakker, Jurgen R. Haanstra, Jurgen R. Haanstra   +2 more
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Mitochondrial Biology and the Identification of Biomarkers of Huntington’s Disease

Neurodegenerative Disease Management, 2020
Apart from finding novel compounds for treating Huntington's disease (HD) an important challenge at present consists in finding reliable read-outs or biomarkers that reflect key biological processes involved in HD pathogenesis. The core elements of HD biology, for example, HTT RNA levels or protein species can serve as biomarker, as could measures from
Andreas Neueder, Michael Orth
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Identification of MHC - molecular biology

Transplant Immunology, 1994
Many of the molecular methods currently in use in the histocompatibility laboratory have been described. The use of a specific technique will depend on the laboratory's requirements. Obviously those laboratories involved in cadaver transplantation will use techniques suitable for single sample analysis which give results within six hours.
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Biology and identification of Aeolothripidae (Thysanoptera) in Australia

Invertebrate Systematics, 1998
The diversity of biologies amongst Australian thrips of the family Aeolothripidae is discussed. In the basal clades of this family species are phytophagous, also sometimes monophagous and univoltine (Cranothrips Bagnall and Cycadothrips Mound). In the most advanced clades, species are obligate predators, often on other thrips species (Franklinothrips ...
Rita Marullo, Laurence A. Mound
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Character Identification in Evolutionary Biology: The Role of the Organism

Theory in Biosciences, 2000
In this article we argue that an organismic perspective in character identification can alleviate a structural deficiency of mathematical models in biology relative to the ones in the physical sciences. The problem with many biological theories is that they do not contain the conditions of their validity or a method of identifying objects that are ...
Günter P. Wagner, Manfred Dietrich Laubichler   +1 more
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