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Nanopore-Based Protein Identification.
Journal of the American Chemical Society, 2022The implementation of a reliable, rapid, inexpensive, and simple method for whole-proteome identification would greatly benefit cell biology research and clinical medicine.
Mazdak Afshar Bakshloo +6 more
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Mitochondrial Biology and the Identification of Biomarkers of Huntington’s Disease
Neurodegenerative Disease Management, 2020Apart from finding novel compounds for treating Huntington's disease (HD) an important challenge at present consists in finding reliable read-outs or biomarkers that reflect key biological processes involved in HD pathogenesis. The core elements of HD biology, for example, HTT RNA levels or protein species can serve as biomarker, as could measures from
Andreas, Neueder, Michael, Orth
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Recent Advances in the System Biology-based Target Identification and Drug Discovery.
Current Topics in Medicinal Chemistry, 2018The enormous quantity of publicly available active chemical ligand and biological receptor data knowledge allows scientists to retreat several open questions by the analysis and systematic integration of these complex unique data. Systems biology plays a
Brijesh Singh Yadav, Vijay Tripathi
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Identification of MHC - molecular biology
Transplant Immunology, 1994Many of the molecular methods currently in use in the histocompatibility laboratory have been described. The use of a specific technique will depend on the laboratory's requirements. Obviously those laboratories involved in cadaver transplantation will use techniques suitable for single sample analysis which give results within six hours.
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DWARF BUNT: Politics, Identification, and Biology
Annual Review of Phytopathology, 1996▪ Abstract Dwarf bunt is a disease of wheat caused by the smut fungus Tilletia controversa Kuhn. Winter wheat (Triticum aestivum L.) is the primary host of economic significance. Although the total acreage affected by dwarf bunt is small relative to total wheat production worldwide, the disease has assumed attention disproportionate to its economic ...
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Advances in the biology, pathogenesis and identification of Pneumocystis pneumonia
Current Opinion in Pulmonary Medicine, 2008Pneumocystis pneumonia remains the most prevalent opportunistic infection in patients with AIDS. It is also a common devastating infection in patients with other causes of altered immunity. Though scientific study of this fungal pathogen is challenging given the inability to propagate the organism outside of the host lung, studies utilizing advanced ...
Bryan J, Krajicek +2 more
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Drug target identification through systems biology
Drug Discovery Today: Technologies, 2015To rationalise drug target selection, we should understand the role of putative targets in biological pathways quantitatively. We review here how experimental and computational network-based approaches can aid more rational drug target selection and illustrate this with results obtained for microbes and for cancer.
Jurgen R. Haanstra, Barbara M. Bakker
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Structural Biology for Target Identification and Validation
Structural biology is catalyzing a paradigm shift in drug discovery towards rational approaches in target identification and validation. Leveraging structural insights obtained through cryo-EM or X-ray crystallography not only enhances the efficiency of drug discovery projects in terms of time and cost, but also significantly improves the likelihood ofYuliya, Dubianok +2 more
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Biology and identification of Aeolothripidae (Thysanoptera) in Australia
Invertebrate Systematics, 1999The diversity of biologies amongst Australian thrips of the family Aeolothripidae is discussed. In the basal clades of this family species are phytophagous, also sometimes monophagous and univoltine ( Cranothrips Bagnall and Cycadothrips Mound). In the most advanced clades, species are obligate predators, often on other thrips species ( Franklinothrips
Laurence A. Mound, Rita Marullo
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Applications of Nonlinear System Identification in Molecular Biology
2006 International Conference of the IEEE Engineering in Medicine and Biology Society, 2006Here we show how nonlinear system identification techniques, such as fast orthogonal search (FOS) and the orthogonal search method (OSM), can be used to analyze gene expression profiles and predict the class to which a profile belongs.
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