Results 31 to 40 of about 927,518 (217)
Nature, 2004 Complete genome sequences have provided a plethora of potential drug targets. But the hard task of finding their weak spots is just beginning, as Caitlin Smith finds out.
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Genetics and molecular biology: identification of dyslipidemia genes [PDF]
Current Opinion in Lipidology, 2010 New approaches to determine which common genetic variants may be responsible for lipid disorders within the wider population particularly the association between clinical phenotype and single nucleotide polymorphisms (SNPs) or genetic loci in multiple genes. These systematic genome-wide association studies (GWAS) have identified several new loci.
Dino Rotondo, Jillian Davidson
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Systems Biology: Identifiability analysis and parameter identification via systems-biology informed neural networks [PDF]
arXiv, 2022 The dynamics of systems biological processes are usually modeled by a system of ordinary differential equations (ODEs) with many unknown parameters that need to be inferred from noisy and sparse measurements. Here, we introduce systems-biology informed neural networks for parameter estimation by incorporating the system of ODEs into the neural networks.
arxiv
Physics of liquid crystals in cell biology [PDF]
arXiv, 2021 The last decade has witnessed a rapid growth in understanding of the pivotal roles of mechanical stresses and physical forces in cell biology. As a result an integrated view of cell biology is evolving, where genetic and molecular features are scrutinized hand in hand with physical and mechanical characteristics of cells. Physics of liquid crystals has
arxiv
Identification of longevity genes with systems biology approaches
Advances and Applications in Bioinformatics and Chemistry, 2009 Identification of genes involved in the aging process is critical for understanding the mechanisms of age-dependent diseases such as cancer and diabetes. Measuring the mutant gene lifespan, each missing one gene, is traditionally employed to identify longevity genes.
John Bush +3 more
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Toxin–antitoxin systems [PDF]
Mobile Genetic Elements, 2013 Toxin-antitoxin (TA) systems are small genetic elements composed of a toxin gene and its cognate antitoxin. The toxins of all known TA systems are proteins while the antitoxins are either proteins or non-coding RNAs. Based on the molecular nature of the antitoxin and its mode of interaction with the toxin the TA modules are currently grouped into five ...
Brigitte Poppenberger +2 more
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Toxins, 2019 Botulinum neurotoxin (BoNT) injections are widely used for facial rejuvenation procedures, and the procerus muscle is a major target in cases of glabellar transverse lines or rhytids.
Younghoon Cho +5 more
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Novel Anatomical Proposal for Botulinum Neurotoxin Injection Targeting Lateral Canthal Rhytids
Toxins, 2022 Botulinum neurotoxin injections near the lateral canthal rhytids are commonly used in cosmetic settings; however, there is a lack of thorough anatomical knowledge, and an effective way to treat them with accumulating knowledge is needed.
Kyu-Ho Yi +5 more
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AI-Aristotle: A Physics-Informed framework for Systems Biology Gray-Box Identification [PDF]
arXiv, 2023 Discovering mathematical equations that govern physical and biological systems from observed data is a fundamental challenge in scientific research. We present a new physics-informed framework for parameter estimation and missing physics identification (gray-box) in the field of Systems Biology.
arxiv
Multi-Target Deep Learning for Algal Detection and Classification [PDF]
2020 42nd Annual International Conference of the IEEE Engineering
in Medicine & Biology Society (EMBC), 2020 Water quality has a direct impact on industry, agriculture, and public health. Algae species are common indicators of water quality. It is because algal communities are sensitive to changes in their habitats, giving valuable knowledge on variations in water quality. However, water quality analysis requires professional inspection of algal detection and
arxiv +1 more source