Results 31 to 40 of about 4,350,325 (326)
SYSTEM IDENTIFICATION CHALLENGES FROM SYSTEMS BIOLOGY
IFAC Proceedings Volumes, 2006 Abstract Systems biology is the understanding through computational modelling of the function of biological systems. New high-throughput experimental technologies can measure simultaneously the levels of expression of thousands of genes. The challenge is to extract knowledge from these data sets in order to understand the regulatory machinery of the ...
Edmund J. Crampin
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In-silico guided chemical exploration of KDM4A fragments hits
Clinical Epigenetics, 2023 Background Lysine demethylase enzymes (KDMs) are an emerging class of therapeutic targets, that catalyse the removal of methyl marks from histone lysine residues regulating chromatin structure and gene expression. KDM4A isoform plays an important role in
Jessica Lombino +15 more
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Toxins, 2022 Postoperative pain after breast reconstruction surgery with the latissimus dorsi flap is a common occurrence. Botulinum neurotoxin (BoNT) injection during surgery is effective in reducing postoperative pain.
Kyu-Ho Yi +3 more
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Circulating tumor cells: biology and clinical significance
Signal Transduction and Targeted Therapy, 2021 Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against ...
Danfeng Lin +10 more
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Scientific Reports, 2023 Species identification is necessary to prevent introductions of exotic plant pests through global trade. Many of these pests are understudied and lack publicly available DNA sequence data on which rapid molecular identification methods can be based.
Frida A. Zink +3 more
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Biology, vulnerabilities and clinical applications of circulating tumour cells
Nature Reviews. Cancer, 2022 In recent years, exceptional technological advances have enabled the identification and interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading to new fields of research and fostering the promise for paradigm ...
A. Ring +3 more
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Nature, 2004 Complete genome sequences have provided a plethora of potential drug targets. But the hard task of finding their weak spots is just beginning, as Caitlin Smith finds out.
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Genetics and molecular biology: identification of dyslipidemia genes [PDF]
Current Opinion in Lipidology, 2010 New approaches to determine which common genetic variants may be responsible for lipid disorders within the wider population particularly the association between clinical phenotype and single nucleotide polymorphisms (SNPs) or genetic loci in multiple genes. These systematic genome-wide association studies (GWAS) have identified several new loci.
Dino Rotondo, Jillian Davidson
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IMA Fungus, 2020 True fungi (Fungi) and fungus-like organisms (e.g. Mycetozoa, Oomycota) constitute the second largest group of organisms based on global richness estimates, with around 3 million predicted species.
R. Lücking +26 more
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Identification of longevity genes with systems biology approaches
Advances and Applications in Bioinformatics and Chemistry, 2009 Identification of genes involved in the aging process is critical for understanding the mechanisms of age-dependent diseases such as cancer and diabetes. Measuring the mutant gene lifespan, each missing one gene, is traditionally employed to identify longevity genes.
John Bush +3 more
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