Results 181 to 190 of about 453,327 (300)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Development and Validation of Algorithms for Systemic Sclerosis Identification in Electronic Health Record Data. [PDF]

ACR Open Rheumatol
Ozen G, O'Rorke M, Romitti P, Domsic R.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Validity of International Classification of Diseases (ICD)-9 and ICD-10 Codes for Medication-Related Osteonecrosis of the Jaw (MRONJ) Among Individuals Prescribed Antiresorptives for Fracture Prevention Across Two Cohorts. [PDF]

Clin Epidemiol
Carbone LD, Le B, Elam RE, Budde E, Huo Z, Finch D, Dodson TB, Gerngross PJ, Fink HA, Adler RA, Weaver F, Lo JC, Barzilay J, Grangaard Johnson L, Schousboe JT.   +14 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Use of UK national health databases for detecting intra-cranial aneurysm rupture in the Risk of Aneurysm Rupture (ROAR) study. [PDF]

PLOS Digit Health
Hall S, Birks J, Ewbank F, Gaastra B, Agarwal G, Bhatt H, Bonifacio G, Dainton A, Dando A, Elmarawany M, Hannan C, Harris L, Harris M, Jung J, Kalyal N, Loan JJ, Lowes D, Maripi H, Motiwala M, Myers M, O'Brien F, Ogbu I, Parton W, Rowland D, Saeed F, Taylor E, Venturini S, Bulters D, ROAR Collaborative.   +28 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Routine data are not 'dirty' data: how to approach using routine data for research. [PDF]

BMJ Health Care Inform
Duffy G, Cunningham A, Sharma V, Lawton T.   +3 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Accurately identifying cirrhosis and its complications to create the novel statewide Indiana digital cirrhosis registry. [PDF]

Sci Rep
Desai AP, Shamseddeen H, Lembcke L, Hui SL, Nephew LD, Ghabril MS, Orman ES, Chalasani N.   +7 more
europepmc   +1 more source