Results 101 to 110 of about 55,177 (246)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Contested Meanings: Audience Studies and the Concept of Cultural Identity

open access: yesIntexto, 2008
O objetivo do ensaio é duplo: primeiro, por meio de uma exposição literária, André Jansson tenta definir o significado de identidade cultural. Como o conceito deve ser definido teoricamente? E como ele deve ser diferenciado do conceito geral de identidade e de tipos mais específicos (e frequentemente usados de forma irresponsável), como identidade ...
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Meaning in life from a cultural perspective: the role of cultural identity, perceived social support, and resilience among Chinese college students

open access: yesHumanities & Social Sciences Communications
For college students facing psychological “weaning”, the lack of a sense of meaning in life can lead to a series of psychological and behavioral problems, such as anxiety, depression, and even increased risk of aggressive behavior or suicide.
Song Zhou   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

KOSMOLOGI RUANG ADAT SEBAGAI IDENTITAS PEMUKIMAN KAMPUNG NAGA, TASIKMALAYA - JAWA BARAT

open access: yesTeknik, 2014
[Title: Traditional Cosmologycal Space as Kampung Naga Setlement Identity, Tasikmalaya - Jawa Barat] Located far from the city, an architectural masterpiece grows and developes in traditional settlement.
Meta Khairunnisa
doaj  

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