Results 131 to 140 of about 6,561,712 (300)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Meaning in life from a cultural perspective: the role of cultural identity, perceived social support, and resilience among Chinese college students

open access: yesHumanities & Social Sciences Communications
For college students facing psychological “weaning”, the lack of a sense of meaning in life can lead to a series of psychological and behavioral problems, such as anxiety, depression, and even increased risk of aggressive behavior or suicide.
Song Zhou   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Contested Meanings: Audience Studies and the Concept of Cultural Identity

open access: yesIntexto, 2008
O objetivo do ensaio é duplo: primeiro, por meio de uma exposição literária, André Jansson tenta definir o significado de identidade cultural. Como o conceito deve ser definido teoricamente? E como ele deve ser diferenciado do conceito geral de identidade e de tipos mais específicos (e frequentemente usados de forma irresponsável), como identidade ...
openaire   +2 more sources

Working Tourists: Identity Formation in a Leisure Space [PDF]

open access: yes, 2007
Young budget travellers who work as they travel the world have often escaped academic attention. This thesis will begin to correct this omission by illustrating how the working and travelling practices of these young budget travellers affects their ...
Duncan, T.J.C.E, Duncan, T J C E
core  

KOSMOLOGI RUANG ADAT SEBAGAI IDENTITAS PEMUKIMAN KAMPUNG NAGA, TASIKMALAYA - JAWA BARAT

open access: yesTeknik, 2014
[Title: Traditional Cosmologycal Space as Kampung Naga Setlement Identity, Tasikmalaya - Jawa Barat] Located far from the city, an architectural masterpiece grows and developes in traditional settlement.
Meta Khairunnisa
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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