Results 201 to 210 of about 58,397 (264)

What are 'biohackers' hacking? Identifying motivations and meaning-making frameworks. [PDF]

Med Humanit
Lorrimar V.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Culture eats evidence for breakfast: how culture influences implementation of evidence-based practices. [PDF]

Implement Sci Commun
Nilsen P, Kirk JW.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Docendo discimus: promoting patient personhood in clinical supervision - a critical phenomenological study of reciprocal professional formation in medicine. [PDF]

Philos Ethics Humanit Med
Greenbrook JTV, Ioannou M, Lemieux-Cumberlege AH, Gross L.   +3 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

More patterns on palliative care identity: An autoethnography contribution. [PDF]

Palliat Support Care
Neto IG, Sapeta P, Almeida A, Meneres S.
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Identity Construction and the Multiple Meanings of Homemade Clothes in Contemporary British Culture

, 2014
openaire   +2 more sources

Cultural recognition for women with diabetes using alternative health care in Malay Ethnic, West Kalimantan, Indonesia: A focused ethnography. [PDF]

Belitung Nurs J
Parliani, Pearkao C.
europepmc   +1 more source