Results 91 to 100 of about 518,478 (263)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Sensor-fusion-based biometric identity verification

, 1998
Future generation automated human biometric identification and verification will require multiple features/sensors together with internal and external information sources to achieve high performance, accuracy, and reliability in uncontrolled environments. The primary objective of the proposed research is to develop a theoretical and practical basis for
Carlson, J. J., Bouchard, A. M., Osbourn, G. C., Martinez, R. F., Bartholomew, J. W., Jordan, J. B., Flachs, G. M., Bao, Z., Zhu, L.   +8 more
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Sense of safety or meaning in danger? Real-contact stick fighting as an imagistic ritual

Frontiers in Psychology
It is a common assumption that human behavior is guided by a desire to feel safe and avoid harm. However, this view is challenged by the popularity of high-risk leisure sport and other practices that involve subjecting oneself to a considerable danger ...
Teemu Pauha
doaj   +1 more source

Metamorphosis and identity : psychoanalytical notes to Miyazaki’s Spirited Away and Howl’s Moving Castle [PDF]

, 2009
Far greater liberties can be taken by animation than by live-action films The possibilities of the narratives are enriched by unrestricted visual images that offer unique means of exploring and portraying states of desire, conscious and unconscious ...
Brockmann, Madalina
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Fusion collaboration in global teams. [PDF]

This essay introduces a new model for facilitating collaboration in global teams that leads to creatively realistic solutions to global problems. The conceptualization for the fusion model of global team collaboration draws on the culinary tradition of ...
Brett, JM, Janssens, Maddy
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Weight Priors for Learning Identity Relations [PDF]

, 2019
Learning abstract and systematic relations has been an open issue in neural network learning for over 30 years. It has been shown recently that neural networks do not learn relations based on identity and are unable to generalize well to unseen data. The
Kopparti, R. M., Weyde, T.
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source