Results 71 to 80 of about 344,308 (202)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Resistance mutations and CTL epitopes in archived HIV-1 DNA of patients on antiviral treatment: toward a new concept of vaccine. [PDF]
PLoS ONE, 2013 Eleven patients responding successfully to first-line antiretroviral therapy (ART) were investigated for proviral drug resistance mutations (DRMs) in RT by ultra-deep pyrosequencing (UDPS).
Jennifer Papuchon +8 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Social media and adolescents: Possibilities for satisfying psychological needs. Results of in-depth interviews with Russian pupils and university students [PDF]
World of Media, 2020 The article examines the possibilities for satisfying adolescents’ basic psychological needs in a digital environment. The study is based on a series of in-depth interviews with youth representatives with profound knowledge of digital technologies that ...
Anna Tolokonnikova +2 more
doaj
Identity-Aware Textual-Visual Matching with Latent Co-attention
, 2017 Textual-visual matching aims at measuring similarities between sentence descriptions and images. Most existing methods tackle this problem without effectively utilizing identity-level annotations.
Li, Hongsheng +4 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
On Using Backpropagation for Speech Texture Generation and Voice Conversion
, 2018 Inspired by recent work on neural network image generation which rely on backpropagation towards the network inputs, we present a proof-of-concept system for speech texture synthesis and voice conversion based on two mechanisms: approximate inversion of ...
Bengio, Samy +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
, 2014 We consider the image classification problem via kernel collaborative representation classification with locality constrained dictionary (KCRC-LCD). Specifically, we propose a kernel collaborative representation classification (KCRC) approach in which ...
Li, Hui +5 more
core +1 more source