Results 191 to 200 of about 50,635 (295)

Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1614-1627, June 2026.
Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri, Islam R. Younis, Shadia I. Jalal, Theodore F. Logan, Rohan Maniar, Steven M. Bray, Sara K. Quinney, Zeruesenay Desta, Todd C. Skaar, James E. Tisdale, Tyler Shugg   +10 more
wiley   +1 more source

State‐Level Politics in Forest Governance: The Role of the Narrative‐Policy Nexus in the Brazilian Amazon

Environmental Policy and Governance, Volume 36, Issue 3, Page 476-490, June 2026.
ABSTRACT Deforestation and its social impacts are an enduring challenge in agrarian frontiers, especially in the tropics. Fueled by global demand for commodities, this process is mediated by ideas, concepts, meanings, and policies that uphold socioenvironmental degradation. A key and understudied—arena in which this mediation occurs is the sub‐national
Gabriela Russo Lopes, Fabio de Castro
wiley   +1 more source

MI-Net: a dual-stream feature network based on Mamba-convolutional neural network (CNN) fusion to predict intradialytic hypotension using multimodal data. [PDF]

Quant Imaging Med Surg
Deng B, Shen J, Feng C, Ai Q, Zhou Q.
europepmc   +1 more source

Real‐world, multi‐omics validation of the clinical relevance of molecular taxonomy for myelodysplastic syndromes (MDS)

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Myelodysplastic syndromes (MDS) are clinically and biologically diverse disorders, emphasizing the need for personalized treatment approaches. The International Working Group for Prognostication of MDS (IWG_PM) recently introduced a molecular classification, referred to as the MDS taxonomy, that categorizes patients into 16 subgroups based on ...
Giulia Maggioni, Gabriele Todisco, Elisabetta Sauta, Luca Lanino, Somedeb Ball, Jan P. Bewersdorf, Tariq Kewan, Najla H. Al Ali, Pierre Fenaux, Uwe Platzbecker, Valeria Santini, Zhuoer Xie, Andrew M. Brunner, Andrew T. Kuykendall, John M. Bennett, Rena Buckstein, Rafael Bejar, Hetty E. Carraway, Amy E. DeZern, Elizabeth A. Griffiths, Stephanie Halene, Robert P. Hasserjian, Alan F. List, Sanam Loghavi, Olatoyosi Odenike, Eric Padron, Mrinal M. Patnaik, Gail J. Roboz, Maximilian Stahl, Mikkael A. Sekeres, David P. Steensma, Michael R. Savona, Justin Taylor, Mina L. Xu, David A. Sallman, Stephen D. Nimer, Christopher S. Hourigan, Andrew H. Wei, Alessia Campagna, Marta Ubezio, Elena Riva, Denise Ventura, Nicole Pinocchio, Matteo Zampini, Alessandro Buizza, Antonio Russo, Francesco Pesce, Saverio D'Amico, Gianluca Asti, Mattia Delleani, Erica Travaglino, Cristina A. Tentori, Ivan Ferrari, Alessandra Crespi, Giulia Figini, Maria Di Matteo, Matteo Brindisi, Nicla Manes, Chiara Milanesi, Laura Crisafulli, Francesca Ficara, Gastone Castellani, Uma M. Borate, Fabio Efficace, Steven D. Gore, Tae K. Kim, Maria Diez‐Campelo, Arjan A. van de Loosdrecht, Navel Daver, Maria Rozman, Alberto Orfao, Sa A. Wang, Kathryn Foucar, Marcelo Iastrebner, Phillip Scheinberg, Yasushi Miyazaki, Yazan F. Madanat, Aref Al‐Kali, Moshe Mittelmann, Thomas Cluzeau, Lionel Ades, Ulrich Germing, Guillermo Garcia‐Manero, Shahram Kordasti, Torsten Haferlach, Amer M. Zeidan, Rami S. Komrokji, Matteo G. Della Porta, An international study on behalf of GenoMed4all, Synthema, and icMDS consortia   +90 more
wiley   +1 more source

The value of pleth variability index in predicting hypotension during maintenance hemodialysis: a prospective observational multicenter study (PVi-HD study). [PDF]

BMC Nephrol
Li J, Xu Q, Li F, Yang T, Gao C, Li Y, Zhou J, Cao Y, Tong C, Lu W, Wu Y.   +10 more
europepmc   +1 more source

Recurrent IDH-mutant astrocytoma WHO grade 4 diagnosed during pregnancy: case report with literature review. [PDF]

Front Oncol
Tleubergenov MA, Bakbayeva A, Zhamoldin DK, Doskaliyev A, Urazova UM, Tolepbergenova AD, Nurpeisov AZ, Takenov ZT, Akshulakov S.   +8 more
europepmc   +1 more source

Extracellular Vesicles in the Biology and Liquid Biopsy Diagnostics of Pediatric High‐Grade Glioma – Emerging Findings and Opportunities

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Liquid biopsy has emerged as an important diagnostic paradigm impacting care across multiple cancer indications. This is also an area of great interest in pediatric solid tumours, including those affecting the central nervous system (CNS). Of special concern are pediatric high‐grade gliomas (pHGGs) due to the associated diagnostic complexities,
Samia Jahouri, Laura Montermini, Nadim Tawil, Mahsa Jalali, Livia Garzia, Nada Jabado, Janusz Rak   +6 more
wiley   +1 more source

<i>DLG2</i>-<i>DLG4</i> Expression Is Associated with Improved Survival and a Synaptic Gene Signature in Lower-Grade Glioma. [PDF]

Cancers (Basel)
Gaia F, Dal-Pizzol HR, Malafaia O, Roesler R, Isolan GR.   +4 more
europepmc   +1 more source

IDH Gene Family [PDF]

, 2020
openaire   +1 more source

Phase Separation‐Mediated SRF/P54nrb Transcription Complex Shapes the Vasculature Microenvironment via Upregulating OLFML3 in Glioblastoma

MedComm, Volume 7, Issue 6, June 2026.
We identified SRF as the key TF significantly associated with the malignant phenotype and poor prognosis of GBM. SRF forms a transcriptional complex with P54nrb via phase separation to upregulate the expression of OLFML3. OLFML3 activates ECs and promotes angiogenesis by degrading ECM, releasing proangiogenic factors, enhancing cell–cell adhesion, and ...
Zetao Chen, Yujie Zhang, Liwei Hao, Chenya Feng, Chuangyuan Wang, Tianjing Ai, Peiqian Hu, Jingsen Ji, Shengsong Fu, Taoliang Chen, Fabing Zhang, Liang Zhao, Yiquan Ke   +12 more
wiley   +1 more source