Results 51 to 60 of about 318,904 (273)

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

The effectiveness of Schroth exercises in adolescents with idiopathic scoliosis: A systematic review and meta-analysis

South African Journal of Physiotherapy, 2019
Background Adolescent idiopathic scoliosis (AIS) is one of the most common structural spinal deformities in adolescents, becoming apparent around the time of puberty.
M. Burger, W. Coetzee, Lenka Z. du Plessis, Larissa Geldenhuys, Francois-Pierre Joubert, E. Myburgh, C. van Rooyen, N. Vermeulen   +7 more
semanticscholar   +1 more source

Health-related quality of life in syndromic scoliosis treated by segmental pedicle screw instrumentation: a case-control study

Acta Orthopaedica
Background and purpose: Deformity correction with pedicle screw instrumentation in adolescent idiopathic scoliosis has been shown to improve the health-related quality of life (HRQoL), while evidence on syndromic scoliosis is limited. Syndromic patients
Henri Sallinen, Antti Saarinen, Arimatias Raitio, Matti Ahonen, Ilkka Helenius   +4 more
doaj   +1 more source

Epilepsy syndromes classification

Epilepsia Open, EarlyView.
Abstract Epilepsy syndromes are distinct electroclinical entities which have been recently defined by the International League Against Epilepsy Nosology and Definitions Task Force. Each syndrome is associated with “a characteristic cluster of clinical and EEG features, often supported by specific etiologic findings”.
Elaine C. Wirrell, Nicola Specchio, Rima Nabbout, Phillip L. Pearl, Kate Riney   +4 more
wiley   +1 more source

Review of scoliosis-specific exercise methods used to correct adolescent idiopathic scoliosis

Archives of Physiotherapy, 2019
BackgroundAdolescent idiopathic scoliosis (AIS) refers to a spinal curvature of an unknown origin diagnosed in otherwise healthy children. A conservative treatment approach includes physiotherapy scoliosis-specific exercises (PSSE) with or without ...
Joseph M Day, J. Fletcher, Mackenzie Coghlan, Terrence Ravine   +3 more
semanticscholar   +1 more source

Early childhood anomalies of the hip occur at a similar frequency in patients with idiopathic scoliosis and in healthy individuals – questionnaire for parents

Advances in Rehabilitation, 2017
Introduction: Improper hip joint development may lead to numerous unfavourable changes in the musculoskeletal system. The aim of this research was to determine how often adolescents with idiopathic scoliosis and their healthy counterparts experienced ...
Stępień Agnieszka, Guzek Katarzyna, Czubak Jarosław, Surowińska Joanna, Stępowska Jolanta, Kiebzak Wojciech   +5 more
doaj   +1 more source

The Influence of Genetics in the Early Development of Axial Postural Abnormalities in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Postural abnormalities (PA) can complicate Parkinson's disease (PD). While age and motor severity are established predictors, the genetic role remains underexplored. Objective To evaluate the influence of major genetic variants on PA development in PD over 4 years.
Ilaria A. Di Vico, Silvia Gallo, Eleonora Bertoncello, Claudia Ledda, Michele Tinazzi, Leonardo Lopiano, Carlo Alberto Artusi   +6 more
wiley   +1 more source

Is Sacral Extension a Risk Factor for Early Proximal Junctional Kyphosis in Adult Spinal Deformity Surgery? [PDF]

, 2020
Study designRetrospective cohort study.PurposeTo investigate the role of sacral extension (SE) for the development of proximal junctional kyphosis (PJK) in adult spinal deformity (ASD) surgery.Overview of literatureThe development of PJK is ...
Ames, Christopher, Bess, Shay, Burton, Douglas, Decker, Sebastian, Hart, Robert, Klineberg, Eric, Krettek, Christian, Lafage, Renaud, Lafage, Virginie, Schwab, Frank J, Smith, Justin S   +10 more
core  

Measures of Health-Related Quality of Life Outcomes in Pediatric Neurosurgery: Literature Review [PDF]

, 2019
Background Improving value in healthcare means optimizing outcomes and minimizing costs. The emerging pay-for-performance era requires understanding of the effect of healthcare services on health-related quality of life (HRQoL).
Desai, Virendra R., Gadgil, Nisha, Lam, Sandi K., Raskin, Jeffrey S., Saad, Shahbaz   +4 more
core   +1 more source

Impact of Growth Hormone Treatment in Children From an Extended Family With ACAN‐Related Short Stature

Clinical Genetics, EarlyView.
This study evaluated growth hormone (GH) therapy in children from an extended family with genetically confirmed ACAN‐related short stature. While GH treatment improved growth velocity, the response varied among individuals, and its long‐term impact on final adult height remains to be determined.
Einat Shalev‐Goldman, Ayman Asaly, Hadas Ityel, Ben Pode‐Shakked, Dalit Modan‐Moses, Yael Levy‐Shraga   +5 more
wiley   +1 more source