Results 61 to 70 of about 41,059 (248)

Adult‐Onset Still's Disease Complicated by Secondary Hemophagocytic Lymphohistiocytosis: A Case Report

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Adult‐onset Still's disease (AOSD) is a rare autoinflammatory disorder characterized by fever, rash, joint pain, and elevated ferritin levels. Systemic inflammation can trigger an exaggerated immune response, leading to secondary hemophagocytic lymphohistiocytosis (HLH).
Vasileios Patriarcheas, Vasiliki Gougoula, Michail Makris, Athanasios Penopoulos, Eleftheria Ztriva, Stavroula Bountola, Theodoros Dimitroulas, Christos Savopoulos, Georgia Kaiafa   +8 more
wiley   +1 more source

The European Medicines Agency review of eltrombopag (Revolade) for the treatment of adult chronic immune (idiopathic) thrombocytopenic purpura: summary of the scientific assessment of the Committee for Medicinal Products for Human Use

Haematologica, 2011
On 11th March 2010, the European Commission issued a marketing authorization valid throughout the European Union for Revolade for the treatment of adult chronic immune (idiopathic) thrombocytopenic purpura.
Maria Nieto, G. Calvo, I. Hudson, P. Feldschreiber, David Brown, C. Lee, G. Lay, A. Valéri, E. Abadie, Angela E. Thomas, F. Pignatti   +10 more
semanticscholar   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1405-1421, December 2025.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

An Umbrella Review of Meta‐Analyses on the Efficacy and Safety of Eltrombopag in Immune Thrombocytopenia

Health Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims Immune thrombocytopenia (ITP) is an autoimmune disorder with increased bleeding risk. Eltrombopag, an oral thrombopoietin receptor agonist, is widely used after corticosteroids or immunoglobulins. Multiple meta‐analyses support its efficacy, yet safety concerns persist. We conducted an umbrella review to synthesize evidence
Mahsa Dabir, Maryam Kamrani Mousavi, Shervin Manteghi, Mohammad Amin Mansoori, Fatemeh Karpasand, Fatemeh Zoghi, Mehrdad Payandeh   +6 more
wiley   +1 more source

Open heart surgery for cyanotic heart disease in a child with immune thrombocytopenic purpura:a case report

Indian Journal of Anaesthesia, 2007
Acute immune thrombocytopenic purpura in children, though a benign self limiting condition, at times complicated with life threatening haemorrhage. In spite of bleeding episode it is inevitable that surgical procedure will be performed on patients with ...
Minati Choudhury, Nirvik Pal, Usha Kiran
doaj  

Development of Machine‐Assisted, Human‐Centred Bone Marrow Cell Classification: Feasibility Analysis in Patients With Myelodysplastic Syndromes

eJHaem, Volume 6, Issue 6, December 2025.
ABSTRACT Background Cytomorphological examination and classification of bone marrow (BM) cells using a microscope is essential for diagnosing various diseases affecting the haematopoietic system. However, this requires expertise, is effort‐intensive and is inherently subjective.
Kiyoyuki Ogata, Yuto Mochimaru, Leonie Saft, Gerrit Sijm, Bouchra Badaoui, Canan Alhan, Carole Almire, Yosuke Kato, Daisuke Sakamoto, Naoko Chiba, Naho Murata, Nana Kasai, Kazuma Sei, Naoya Kawahara, Mika Ogata, Nicolas Chapuis, Orianne Wagner‐Ballon, Arjan van de Loosdrecht, Yumi Yamamoto   +18 more
wiley   +1 more source

Severe thrombocytopenia in patients with idiopathic pulmonary arterial hypertension provided several strategies for lung transplantation

Pulmonary Circulation, 2020
While the prognosis of idiopathic pulmonary arterial hypertension has improved significantly due to newer medications, lung transplantation remains a critical therapeutic option for severe pulmonary arterial hypertension.
Takayuki Kobayashi, Ayako Shigeta, Jiro Terada, Nobuhiro Tanabe, Toshihiko Sugiura, Seiichiro Sakao, Kohei Taniguchi, Takahiro Oto, Koichiro Tatsumi   +8 more
doaj   +1 more source

Acquired Idiopathic ADAMTS13 Activity Deficient Thrombotic Thrombocytopenic Purpura in a Population from Japan

PLoS ONE, 2012
Thrombotic thrombocytopenic purpura (TTP) is a type of thrombotic microangiopathy (TMA). Studies report that the majority of TTP patients present with a deficiency of ADAMTS13 activity.
M. Matsumoto, C. Bennett, A. Isonishi, Z. Qureshi, Y. Hori, M. Hayakawa, Y. Yoshida, H. Yagi, Y. Fujimura   +8 more
semanticscholar   +1 more source

IDIOPATHIC THROMBOCYTOPENIC PURPURA ASSOCIATED WITH MULTIPLE SPLEENS: A CASE REPORT

, 2023
Thaisa Frediani Bergamaschi, Larissa Felcar Hil, Isabel Cristina Hilgert Genz, Tiago Luan Branchi, Luiz Eduardo de Paula, Cecilia Resende Brunow Bazzo, Neide Tomimura Costa, Meline Angélica Cunha Rotter Ferreira, Anna Hermínia Castro Gomes de Amorim, Priscila Beatriz de Souza Medeiros   +9 more
openalex   +1 more source

Recurrent Acute Myocardial Infarction in Patients with Immune Thrombocytopenic Purpura

Journal of Patient-Centered Research and Reviews, 2014
Immune thrombocytopenic purpura (ITP), also known as idiopathic thrombocytopenic purpura, is an acquired immune-mediated disease of adults and children characterized by a transient or persistent decrease of platelets and, depending upon the degree of ...
Fengyi Shen, Tonga Nfor, Tanvir Bajwa
doaj   +1 more source