Results 141 to 150 of about 101,741 (257)
Four Afrotropical Culicoides species are recorded in Mauritius with suspected or historically involvement in BTV and EHDV transmission. All species were distributed all over the island. While intra‐specific morphological variations were detected, genetic analyses did not reveal any cryptic diversity. Abstract Viruses transmitted by biting midge species
Diana P. Iyaloo +15 more
wiley +1 more source
A Topology Optimization Framework for the Inverse Design of Nonlinear Mechanical Metamaterials
This work uses topology optimization to design unit cells for mechanical metamaterials with a prescribed nonlinear stress–strain response. The framework adds contact and postbuckling modeling to synthesize microstructures for three highly nonlinear responses, including pseudoductile behavior, monostable with snap‐through buckling, and bistable ...
Charlie Aveline +2 more
wiley +1 more source
Time‐resolved SAXS reveals how physiologically relevant metal ions shape the earliest conformational responses of monomeric α‐synuclein. Fe3+ induces rapid compaction, Cu2+ generates heterogeneous and partially folded ensembles, while Mn2+ and Zn2+ cause only modest changes.
Rebecca Sternke‐Hoffmann +3 more
wiley +1 more source
ABSTRACT Ovarian Cancer (OC), the deadliest gynecological malignancy, poses a major therapeutic challenge in advanced stages owing to its high recurrence rate and metastatic potential. In this regard, it is noteworthy that immunotherapy has recently gained significant attention in OC treatment, a phenomenon attributable to notable advances in over‐the ...
Liying Wang +4 more
wiley +1 more source
Parkinson's disease‐associated protein α‐synuclein can assemble into liquid condensates under strongly perturbed in vitro and in vivo experimental conditions, including high protein concentration, macromolecular crowding, and when attached to various tags with cross‐linking ability.
Simran Arora +1 more
wiley +1 more source
This graphical abstract illustrates the bidirectional causal relationships between gut microbiota and brain network connectivity identified using Mendelian randomization analysis. Genome‐wide association study data from the MiBioGen consortium (gut microbiota) and the UK Biobank (brain imaging‐derived phenotypes across seven resting‐state networks ...
Yule Zeng +5 more
wiley +1 more source
ZSWIM8, an E3 ubiquitin ligase that broadly targets IDR‐rich proteins, drives MiR‐7‐dependent AGO2 degradation and the turnover of many RBPs. Loss of ZSWIM8 leads to MiR‐7 accumulation in oligodendrocyte progenitor cells and myelination defects in the developing brain. ABSTRACT Proteostasis of proteins with intrinsically disordered regions (IDRs) is of
Jing Lei +13 more
wiley +1 more source
ABSTRACT Background and Aims The study aimed to investigate the prevalence, determinants, types, severity, and perceived health consequences of Female Genital Mutilation (FGM) among adolescent girls aged 12–19 in Mogadishu, Somalia. The primary objective was to quantify the burden of different FGM types and identify socio‐cultural predictors. Methods A
Ahmed Abdinasir Abdule +7 more
wiley +1 more source
Abstract TAR DNA‐binding protein 43 (TDP‐43) plays a critical role in RNA metabolism and is incorporated into biomolecular condensates called stress granules. In amyotrophic lateral sclerosis (ALS) and several other neurodegenerative disorders, TDP‐43 undergoes aberrant phase transitions, forming insoluble amyloid aggregates, including fibrils composed
Emily J. Byrd +4 more
wiley +1 more source
An intrinsically disordered protein, Q20, forms transmembrane condensates with albumin‐loaded lipid and hybrid giant vesicles. Condensate insertion and membrane remodeling depend on giant vesicle size and membrane properties, inducing local lipid coupling without leakage and revealing a robust membrane‐condensate interplay.
Paula De Dios Andres +5 more
wiley +1 more source

