Results 21 to 30 of about 101,741 (257)

NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

Nucleic Acids Research, 2010
Mammalian inosine triphosphatase encoded by ITPA gene hydrolyzes ITP and dITP to monophosphates, avoiding their deleterious effects. Itpa− mice exhibited perinatal lethality, and significantly higher levels of inosine in cellular RNA and deoxyinosine in ...
Nona Abolhassani, Daisuke Tsuchimoto, Kunihiko Sakumi   +2 more
exaly   +2 more sources

Breakthrough SARS-CoV-2 outcomes in immune-disordered people during the Omicron era: a prospective cohort study [PDF]

BMJ Public Health
Introduction Immune-deficient/disordered people (IDP) elicit a less robust immune response to COVID-19 vaccination than the general US population. Despite millions of IDP at presumed elevated risk, few population-level studies of IDP have been conducted ...
Emily E Ricotta, Mackenzie Zendt, Fausto Andres Bustos Carrillo, Viviane Callier, Maureen DeGrange, Anita Ginigeme, Lurline Wu, Bevin Manuelpillai, Ana Ortega-Villa   +8 more
doaj   +2 more sources

IDP-PGFE: an interpretable disruption predictor based on physics-guided feature extraction [PDF]

Nuclear Fusion, 2022
Disruption prediction has made rapid progress in recent years, especially in machine learning (ML)-based methods. If a disruption prediction model can be interpreted, it can tell why certain samples are classified as disruption precursors. This allows us
C. Shen, Wei Zheng, Yonghua Ding, X. Ai, F. Xue, Y. Zhong, Nengchao Wang, Li Gao, Zhipeng Chen, Zhoujun Yang, Z. Chen, Y. Pan, J-Text Team   +12 more
semanticscholar   +1 more source

Phanto-IDP: compact model for precise intrinsically disordered protein backbone generation and enhanced sampling

Briefings Bioinform., 2023
The biological function of proteins is determined not only by their static structures but also by the dynamic properties of their conformational ensembles.
Junjie Zhu, Zhengxin Li, Hao Tong, Zhouyu Lu, Ningjie Zhang, Ting Wei, Hai-Feng Chen   +6 more
semanticscholar   +1 more source

IDP-LM: Prediction of protein intrinsic disorder and disorder functions based on language models

PLoS Comput. Biol., 2023
Intrinsically disordered proteins (IDPs) and regions (IDRs) are a class of functionally important proteins and regions that lack stable three-dimensional structures under the native physiologic conditions.
Yihe Pang, Bin Liu
semanticscholar   +1 more source

Optimization of ASP flooding based on dynamic scale IDP with mixed-integer

Applied Mathematical Modelling, 2017
Yulei Ge, Shurong Li
exaly   +2 more sources

Experiences from the Field: A Qualitative Study Exploring Barriers to Maternal and Child Health Service Utilization in IDP Settings Somalia

International Journal of Women's Health, 2021
Background In Somalia, maternal and child health service utilization is unacceptably low. Little is known about factors contributing to low maternal and child health service utilization in Somalia, especially in internally displaced people (IDP) settings.
Adam A Mohamed, T. Bocher, M. Magan, A. Omar, Olive Mutai, S. Mohamoud, Meftuh Omer   +6 more
semanticscholar   +1 more source

ABKHAZIA IN MODERN GEORGIAN WRITING

Arts Academy, 2023
https://artsacademy.kz/magazine/nauchnyj-zhurnal-arts-academy-372023/994-abkhazia-in-modern-georgian ...
Tamar Koberidze, Nino Mindiashvili
doaj   +1 more source

Effects of pH on an IDP conformational ensemble explored by molecular dynamics simulation.

Biophysical Chemistry, 2021
The conformational ensemble of intrinsically disordered proteins, such as α-synuclein, are responsible for their function and malfunction. Misfolding of α-synuclein can lead to neurodegenerative diseases, and the ability to study their conformations and ...
Richard J. Lindsay, R. Mansbach, S. Gnanakaran, T. Shen   +3 more
semanticscholar   +1 more source

The South African IDP and SDF contextualised in relation to global conceptions of forward planning – A review

Town and Regional Planning, 2022
Municipalities across the globe require good planning instruments to address the need for medium- to long-term planning. In South Africa, the Integrated Development Plan (IDP) and the Spatial Development Framework (SDF) could be regarded as the two main ...
Francois Wüst
doaj   +1 more source