Results 21 to 30 of about 3,332 (169)

Water‐Mediated Phosphoryl Wires Stabilize Pathological Tau Fibrils

Angewandte Chemie, EarlyView.
Extended 1D phosphoryl “wires” stabilize in‐register amyloid tau fibrils, as demonstrated by multiple‐quantum spin‐counting NMR, TEM, and MD simulations, using fibrils of tau peptide jR2R3‐P301L (tau295–313) with phosphorylation at S305 or Y310. ABSTRACT Hyperphosphorylation of tau is a hallmark of tauopathies, with specific phosphorylation sites ...
Lokeswara Rao Potnuru, Austin DuBose, Fiona Mon, Mesopotamia S. Nowotarski, Michael Vigers, Boqin Zhang, Chung‐Ta Han, John E. Straub, Songi Han   +8 more
wiley   +2 more sources

Enzymatic Encoding of Topology in an Intrinsically Disordered Single‐Chain Protein

Angewandte Chemie, EarlyView.
Enzymatic intramolecular cross‐linking enables topology control in intrinsically disordered proteins, yielding SCNPs with reproducible cavity architectures. Using β‐casein and microbial transglutaminase, sparse, sequence‐resolved constraints drive compact collapse without inducing secondary structure.
Joshua Johani, Kristin Eichelberger, Olga Guskova, Simbulele Charlotte Dunjwa, Hans Bolinsson, Anna‐Maria Börjesdotter, Lars Nilsson, Doris Jaros, Harald Rohm, Albena Lederer   +9 more
wiley   +2 more sources

aplicação dos precedentes vinculantes

Brazilian Journal of Empirical Legal Studies, 2021
O presente artigo procura avaliar como os juízes de primeiro grau de jurisdição, em especial os que se encontram em processo de vitaliciamento, veem o sistema de decisões vinculantes instituído pelo CPC/2015, principalmente quando lidam com demandas de ...
Carl Olav Smith, Fabio Quintas
doaj   +1 more source

ASPEK ERGONOMI DARI RISIKO PSIKOSOSIAL DI TEMPAT KERJA

Jurnal Ergonomi Indonesia, 2015
Perkembangan ilmu pengetahuan dan teknologi (IPTEK) sangat pesat beberapa dekade terakhir ini telah terbukti memberikan manfaat yang sangat besar bagi kesejahteraan masyarakat, namun tanpa disadari juga menimbulkan dampak negatif seperti meningkatnya ...
IDP Sutjana
doaj   +4 more sources

Rapid Fragment Screening by 19F Steady‐State Free Precession NMR

Angewandte Chemie, EarlyView.
19F$^{19}{\rm F}$ SSFP NMR is a broadband and very sensitive experiment for detecting protein–ligand interactions. The method enables rapid fragment screening at low micromolar protein concentrations, even for challenging drug targets such as intrinsically disordered proteins.
Laura Ruduša, Sintija Ozola, Kostiantyn P. Melnykov, Yaroslav I. Filatov, Serhiy V. Ryabukhin, Raitis Bobrovs, Dmytro M. Volochnyuk, Kristaps Jaudzems, Rihards Aleksis   +8 more
wiley   +2 more sources

Invigorating Health Strategy in an Integrated Design Process

Smart Cities, 2022
Healthy buildings are gaining crucial significance in construction and one health setting for promoting occupants’ health. However, the traditional design process for healthy buildings presents limitations with no specific guidelines.
Stahel Serano Bibang Bi Obam Assoumou, Li Zhu, Christopher Khayeka-Wandabwa   +2 more
doaj   +1 more source

Evaluation of the Satisfaction Level of the IDP with the Basic IDP Facilities Provided

Journal of Engineering Research and Reports, 2022
The prolonged conflict between the Boko-Haram and the Nigerian military has led to the displacement of a lot of people from their communities forcing them to settle into Internally Displace Persons (IDP) camps over these years. This has placed a heavy burden on the government and other non-governmental organizations in the provision of aides and IDP ...
Sani Abdulrahman Tolani, Christian Uchechukwu Akpunonu, Gerald C. Ukah, H. Mshelbara Asabe, I. Nkeleme Emmanuel   +4 more
openaire   +1 more source

İslamcı Dergilerde Hadis Tartışmaları Meseleler, Dönemler ve İsimler, yazar Selim Demirci (İstanbul: İlem, 2022), 152 sayfa, ISBN: 978-625-7800-73-0

Danisname Beşeri ve Sosyal Bilimler Dergisi, 2023
İslamcı düşüncenin oluşumu ve gelişimine katkı sağlayan İslamcı dergiler, 1908’den günümüze tarih, sosyoloji, din, felsefe gibi birçok alana kaynaklık etmiştir. Dergilerdeki tema ve tartışmalar bugün bile güncelliğini korumaktadır.
Kudret Çimen
doaj  

IDP perspectives on IDP participation

Journal of Refugee Studies
Abstract Participation is a humanitarian mantra and a mainstay in development discourse. Some important steps have recently been taken to strengthen meaningful and effective refugee participation, including through refugee-led organizations.
Laura Borrero Fierro, Luz Becerra Panesso, Tetiana Durnieva, Nestor Hernández, Yana Liubymova, Valeriia Vershynina, Rose Kobusinge, Paula Gaviria Betancur, Nadine Walicki, Mark Yarnell, Guadalupe Jolicoeur, Megan Bradley   +11 more
openaire   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source