Results 51 to 60 of about 81,979 (281)
Chameleonic Nature of Aβ: Implications for Alzheimer's and Other Amyloid Diseases
BioEssays, EarlyView.The energy landscape of Aβ reveals its flexible, “chameleon‐like” behavior, enabling diverse structures from disordered to β‐rich forms. This polymorphism facilitates aggregation, contributing to Alzheimer's disease progression, while the flat landscape also allows disaggregation, potentially slowing disease progression compared to prion proteins with ...
Birgit Strodel
wiley +1 more source
Revista do Direito PúblicoVisa o presente artigo analisar as execuções fiscais em relação a alguns municípios que compõem a região do Alto Tietê, notadamente as cidades de Itaquaquecetuba, Mogi das Cruzes e Suzano.
Fábio Camargo +1 more
doaj +1 more source
Invigorating Health Strategy in an Integrated Design Process
Smart Cities, 2022 Healthy buildings are gaining crucial significance in construction and one health setting for promoting occupants’ health. However, the traditional design process for healthy buildings presents limitations with no specific guidelines.
Stahel Serano Bibang Bi Obam Assoumou +2 more
doaj +1 more source
Dynamic protein interactions probed by NMR spectroscopy
Bulletin of the Korean Chemical Society, EarlyView.Abstract Dynamic protein–protein interactions are essential for diverse cellular processes but often evade structural characterization due to their transient, heterogeneous, and disordered nature. This review focuses on how nuclear magnetic resonance (NMR) spectroscopy can provide detailed, residue‐level insights into these complex interactions.
Jaeseok Lee, Jung Ho Lee
wiley +1 more source
Understanding Concerns about Community Relations in Calderdale [PDF]
, 2015 •This study examined attitudes and dispositions towards greater ethnic and religious diversity, as well as community relations more generally, among residents of predominantly white British neighbourhoods.
Busher, Joel +4 more
core +1 more source
Macromolecular High‐Affinity Binding Probed by Advanced Fluorescence Techniques
ChemBioChem, Accepted Article.Due to the extreme sensitivity and the intrinsic selectivity of fluorescence techniques, high‐affinity binding can be measured even at extremely low molecule concentrations in the picomolar range. In particular, modern advanced techniques with fluorescence microscopes have provided considerable methodological advancements in recent years.
Alida Meyer +2 more
wiley +1 more source
Prediction of Pharmacokinetics of IDP-73152 in Humans Using Physiologically-Based Pharmacokinetics
Pharmaceutics, 2022 IDP-73152, a novel peptide deformylase inhibitor with an antibacterial effect against Gram-positive bacteria, is in phase I development. The objective of this study was to develop a physiologically-based pharmacokinetic model (PBPK) for IDP-73152 in ...
Myongjae Lee +4 more
doaj +1 more source
What is Othello’s Secret? [PDF]
, 2015 Explicitly written from the perspective of a second-generation British Cypriot, this article examines the relevance of Shakespeare’s Othello to the modern troubles of Cyprus.
Christofides, R.M.
core +1 more source