Results 81 to 90 of about 16,741 (230)
ZSWIM8, an E3 ubiquitin ligase that broadly targets IDR‐rich proteins, drives MiR‐7‐dependent AGO2 degradation and the turnover of many RBPs. Loss of ZSWIM8 leads to MiR‐7 accumulation in oligodendrocyte progenitor cells and myelination defects in the developing brain. ABSTRACT Proteostasis of proteins with intrinsically disordered regions (IDRs) is of
Jing Lei +13 more
wiley +1 more source
The fundamental question of how to assign NMR resonances to specific atoms in the unit cell is addressed by using the 9Be and 11B spectra of the natural mineral hambergite as a model system. ABSTRACT The NMR interaction tensors of 9Be and 11B of hambergite, Be 2BO 3OH, were derived from single‐crystal NMR experiments.
Jennifer Steinadler +6 more
wiley +1 more source
Abstract Phosphorylated intrinsically disordered proteins (IDPs), such as Bcl2‐associated agonist of cell death (BAD) and Tau, play critical roles in apoptosis and neurodegeneration, yet their instability during recombinant expression due to degradation, aggregation, and dephosphorylation, has limited structural and mechanistic studies.
Cat Hoang Vesely +6 more
wiley +1 more source
Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova +2 more
wiley +1 more source
Designed Water Capture in Terpene Synthase Catalysis
Engineering of water capture in terpene synthases remains very challenging. We identified two regions in the selinadiene synthase active site pocket that can influence deprotonation or water capture in the final catalytic step and demonstrate a designed‐in switch in product outcome.
Prabhakar L. Srivastava +2 more
wiley +1 more source
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin +14 more
wiley +1 more source
Determinants of child handwashing in a IDP camp in Northern Iraq - Qualitative dataset [PDF]
Julie Watson
openalex +1 more source
Mapping Charge Interactions in Intrinsically Disordered Proteins
This study presents analytical models to predict intrachain distances in intrinsically disordered proteins (IDPs), accounting for charge patterning, salt concentration, and electrostatic effects. Validated against single‐molecule FRET data, a minimal‐parameter polymer model is identified that captures key interactions and chain dimensions. These models
Michael Phillips +14 more
wiley +1 more source
O presente trabalho tem por escopo analisar a relação existente entre a essential facility doctrine e a propriedade intelectual, de forma a demonstrar as consequências decorrentes da obrigação do compartilhamento dos padrões tecnológicos essenciais e ...
Caroline Ferreira Feijó Machado +1 more
doaj
The African Union’s Response to Forced Migration: Reinforcing the Nexus between Peace and Security and Refugee/IDP Protection [PDF]
Swikani Ncube
openalex +1 more source

