Results 81 to 90 of about 16,741 (230)

The Ubiquitin Ligase Zinc Finger SWIM Domain‐Containing Protein 8 Regulates Oligodendrocyte Development Through the Argonaute2/MicroRNA‐7 Axis

open access: yesGlia, Volume 74, Issue 5, May 2026.
ZSWIM8, an E3 ubiquitin ligase that broadly targets IDR‐rich proteins, drives MiR‐7‐dependent AGO2 degradation and the turnover of many RBPs. Loss of ZSWIM8 leads to MiR‐7 accumulation in oligodendrocyte progenitor cells and myelination defects in the developing brain. ABSTRACT Proteostasis of proteins with intrinsically disordered regions (IDRs) is of
Jing Lei   +13 more
wiley   +1 more source

Ambiguities in Assigning Single‐Crystal NMR Data to Individual Atoms in the Crystal Structure: A Case Study of Hambergite, Be2BO3OH, by 9Be and 11B NMR Spectroscopy, XRD Measurements and DFT Calculations

open access: yesMagnetic Resonance in Chemistry, Volume 64, Issue 4, Page 400-415, April 2026.
The fundamental question of how to assign NMR resonances to specific atoms in the unit cell is addressed by using the 9Be and 11B spectra of the natural mineral hambergite as a model system. ABSTRACT The NMR interaction tensors of 9Be and 11B of hambergite, Be 2BO 3OH, were derived from single‐crystal NMR experiments.
Jennifer Steinadler   +6 more
wiley   +1 more source

Accessing intractable, phosphorylated intrinsically disordered proteins via a protease‐cleavable inclusion body tag

open access: yesProtein Science, Volume 35, Issue 4, April 2026.
Abstract Phosphorylated intrinsically disordered proteins (IDPs), such as Bcl2‐associated agonist of cell death (BAD) and Tau, play critical roles in apoptosis and neurodegeneration, yet their instability during recombinant expression due to degradation, aggregation, and dephosphorylation, has limited structural and mechanistic studies.
Cat Hoang Vesely   +6 more
wiley   +1 more source

In vitro, cellular and in vivo studies of amyloid oligomers structure and toxicity: Challenges and advances

open access: yesProtein Science, Volume 35, Issue 4, April 2026.
Abstract Oligomeric assemblies of amyloidogenic proteins, such as Aβ, tau, α‐synuclein, amylin, transthyretin, and TDP‐43, are increasingly recognized as key drivers of cellular dysfunction across a range of neurodegenerative and systemic disorders.
Magdalena I. Ivanova   +2 more
wiley   +1 more source

Designed Water Capture in Terpene Synthase Catalysis

open access: yesChemBioChem, Volume 27, Issue 5, 13 March 2026.
Engineering of water capture in terpene synthases remains very challenging. We identified two regions in the selinadiene synthase active site pocket that can influence deprotonation or water capture in the final catalytic step and demonstrate a designed‐in switch in product outcome.
Prabhakar L. Srivastava   +2 more
wiley   +1 more source

Intrinsically Disordered Protein‐Inspired Nanovector‐Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules

open access: yesAdvanced Materials, Volume 38, Issue 17, 20 March 2026.
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin   +14 more
wiley   +1 more source

Mapping Charge Interactions in Intrinsically Disordered Proteins

open access: yesAdvanced Science, Volume 13, Issue 16, 18 March 2026.
This study presents analytical models to predict intrachain distances in intrinsically disordered proteins (IDPs), accounting for charge patterning, salt concentration, and electrostatic effects. Validated against single‐molecule FRET data, a minimal‐parameter polymer model is identified that captures key interactions and chain dimensions. These models
Michael Phillips   +14 more
wiley   +1 more source

Essential facility doctrine e a propriedade intelectual: a imposição do compartilhamento de padrões tecnológicos essenciais frente aos direitos de exclusividade do inventor

open access: yesRevista de Defesa da Concorrência, 2019
O presente trabalho tem por escopo analisar a relação existente entre a essential facility doctrine e a propriedade intelectual, de forma a demonstrar as consequências decorrentes da obrigação do compartilhamento dos padrões tecnológicos essenciais e ...
Caroline Ferreira Feijó Machado   +1 more
doaj  

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