Results 81 to 90 of about 3,295 (113)
A Study on Operação Acolhida From the Humanitarian Logistics Perspective
ABSTRACT This article examines ‘Operação Acolhida,’ Brazil's humanitarian response to the Venezuelan migration crisis, from a humanitarian logistics perspective. It examines whether the shelters established for Venezuelan refugees in Brazil comply with international humanitarian standards.
Isabela Antunes de Souza de Lima +3 more
wiley +1 more source
Rapid Fragment Screening by 19F Steady‐State Free Precession NMR
19F$^{19}{\rm F}$ SSFP NMR is a broadband and very sensitive experiment for detecting protein–ligand interactions. The method enables rapid fragment screening at low micromolar protein concentrations, even for challenging drug targets such as intrinsically disordered proteins.
Laura Ruduša +8 more
wiley +2 more sources
Abstract BACKGROUND Soybean underpins Brazil's agricultural, yet its sustainability is threatened by lepidopteran pests such as Anticarsia gemmatalis. Although insect‐resistant cultivars have long been associated with the constitutive accumulation of quercetin‐derived flavonols, the biochemical mechanisms underlying this resistance remain poorly ...
Jessica Nunes de Assis +9 more
wiley +1 more source
ABSTRACT Background Cardiovascular disease (CVD) risk assessment based on single‐time‐point measurements may inadequately capture the dynamic interplay of obesity, metabolic dysfunction, and chronic inflammation. Understanding their long‐term co‐evolution may improve CVD risk stratification.
Qinggao Wang +4 more
wiley +1 more source
ABSTRACT Introduction Sudden cardiac arrest remains a major cause of global mortality, underscoring the importance of cardiopulmonary resuscitation. Extended reality (XR) technologies, including virtual, augmented, and mixed reality, have recently emerged as innovative approaches to enhance simulation‐based CPR education for nursing and healthcare ...
John Raymund P. Suazo +5 more
wiley +1 more source
AF‐CALVADOS: AlphaFold‐guided simulations of multi‐domain proteins at the proteome level
Abstract Deep‐learning methods have transformed our ability to predict the three‐dimensional structures of folded proteins from sequence, and coarse‐grained simulations have made it possible to study intrinsically disordered proteins at the proteome scale. More than half of human proteins, however, contain mixtures of disordered regions and one or more
Sören von Bülow +2 more
wiley +1 more source
Enzymatic Encoding of Topology in an Intrinsically Disordered Single‐Chain Protein
Enzymatic intramolecular cross‐linking enables topology control in intrinsically disordered proteins, yielding SCNPs with reproducible cavity architectures. Using β‐casein and microbial transglutaminase, sparse, sequence‐resolved constraints drive compact collapse without inducing secondary structure.
Joshua Johani +9 more
wiley +2 more sources
Sequence determinants of the hypomobility of intrinsically disordered proteins in SDS‐PAGE
Abstract Proteins with intrinsically disordered regions (IDRs) migrate at a higher apparent molecular weight in sodium dodecyl sulfate (SDS)‐polyacrylamide gel electrophoresis, complicating their analysis and identification. Here, we investigate the sequence determinants of the hypomobility of IDRs using a series of synthetic low‐complexity domains. We
Ankush Garg +2 more
wiley +1 more source
ABSTRACT Based upon substantive professional engagement over two decades and the collective action of diverse professionals, this conceptual paper proposes that translational science (TS) is best understood as a meta‐discipline. As with Science, Technology, Education, and Mathematics (STEM) or Information Sciences, meta‐disciplines rely on coherent ...
Shannon L. Casey +3 more
wiley +1 more source

