Results 171 to 180 of about 2,908,134 (284)

Near‐Infrared Imaging of H2O2 in Plants With Nanosensors Under Environmentally Changing Conditions

Advanced Materials, EarlyView.
This paper reports a ratiometric nanosensor enabling robust, multivariate detection of stress signals (H2O2) in plants, with high resistance to light fluctuations and mechanical disturbances. Single‐walled carbon nanotubes serve as the sensor, Egyptian Blue nanosheets serve as a stable reference, and plant autofluorescence serves as a label‐free ...
Jiaqi Li, Bjoern F. Hill, Chen Ma, Juliana Gretz, Tanuja Kistwal, Janus A. C. Wartmann, Justus T. Metternich, Juan Pablo Giraldo, Sebastian Kruss   +8 more
wiley   +1 more source

Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz. [PDF]

Mol Syst Biol
Schmidt C, Franken J, Turei D, Prymidis D, Daley M, Frezza C, Saez-Rodriguez J.   +6 more
europepmc   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Genome-Based Inference of a 50-Kilobase Collinear Synteny Block Containing Genes Predicted to Confer Antimicrobial Resistance and Conjugation Is Widespread Across a Putative Genomic Island in Alpha-Proteobacteria. [PDF]

Microorganisms
Cubillas C, Dávalos A, García-de Los Santos A.   +2 more
europepmc   +1 more source

AI‐Powered Framework for Evaluating Drug Efficacy for Three‐Dimensional In Vitro Cancer Models in Robot‐Assisted Production

Advanced Robotics Research, EarlyView.
An AI‐powered, robot‐assisted framework automatically produces, images, and analyzes 3D tumor spheroids to evaluate drug efficacy. Integrated modules handle spheroid formation, live/dead staining, brightfield imaging, and automated image analysis, including spheroid segmentation, viability and metrics to assess the drug treatment efficacy. The workflow
Dalia Mahdy, Jesus Nieves, Lukas Königer, Matthias Peindl, Fabio Erhard, Marc Möllmann, Anke Klingner, Markus Münig, Bibin Babu, Thomas Schwarz, Marco Metzger, Gudrun Dandekar, Maximiliane Wußmann, Jan Hansmann   +13 more
wiley   +1 more source

Transitioning from Transcriptomics to Proteomics: Enhancing Mechanistic Accuracy in PBPK Modeling via Absolute Protein Abundances. [PDF]

CPT Pharmacometrics Syst Pharmacol
Ning C, Pugliano A, Winter M, Wu K, Annaert P.   +4 more
europepmc   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Paired TIR-NLRs of <i>Arabidopsis thaliana</i> have diverse recognition and activation mechanisms. [PDF]

Front Plant Sci
Burdett H, Holmes TL, Ahn HK.
europepmc   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

An Immune Dysfunction Signature Score Predicts Survival in MDS Patients: Insights From a Longitudinal, Multicenter Study. [PDF]

Cancer Sci
Wang YH, Gurnari C, Visconte V, Durmaz A, Guarnera L, Lee WH, Yao CY, Jerez A, Gurashi K, Batta K, Hou HA, Chou WC, Patnaik MS, Maciejewski J, Wiseman DH, Lin CC, Tien HF.   +16 more
europepmc   +1 more source