Results 211 to 220 of about 385,555 (227)

Diagnostic Accuracy of Immature Granulocyte Count for Early Sepsis Detection: A Comparative Evaluation With C-Reactive Protein and Procalcitonin. [PDF]

Cureus
Taver R, Gupta V, Saxena P, Sharma J, Yadav A, Humne A.   +5 more
europepmc   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Domain-specific motor skill outcomes following a structured play-based motor intervention in preschool children: a cluster-randomized controlled trial. [PDF]

Front Sports Act Living
Agnese M, Massaro S, Cottone R, Scardina A, Lo Dico F, Honório S, Bellafiore M, Tabacchi G.   +7 more
europepmc   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Lamin-ating the genome: quantitative gatekeeping of replication initiation. [PDF]

Trends Cell Biol
Parasar B, Moghadami S, Tan L.
europepmc   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Effectiveness of virtual reality-based rehabilitation on quality of life and upper extremity functions among stroke survivors: A systematic review and meta-analysis. [PDF]

Int J Nurs Stud Adv
Tan RR, Liaw SY, Thng YYQ, Ruksakulpiwat S, Batalik L, Chong MS.   +5 more
europepmc   +1 more source

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

Exercise for myeloma patients with bone disease: a scoping review. [PDF]

Support Care Cancer
Land J, McCourt O, Kyriakou C, Fisher A, Yong K.   +4 more
europepmc   +1 more source

Remotely Delivered Nutrition Interventions with or Without Physical Activity Interventions in Adults with Cardiovascular Diseases: A Systematic Review of Randomized Controlled Trials. [PDF]

Healthcare (Basel)
Dimopoulou M, Isakoglou M, Hoes J, Androutsos O.   +3 more
europepmc   +1 more source