Results 191 to 200 of about 542,367 (279)

Immune System Development—Pro Tips for Paediatricians

Acta Paediatrica, EarlyView.
ABSTRACT There are many misconceptions about the immune system in children, its impact on infectious disease susceptibility and its role in the rapidly increasing rates of immune mediated diseases in industrialized societies. In this mini review, I will discuss common believes and the data supporting or countering such believes, with a focus on ...
Petter Brodin
wiley   +1 more source

Trained Immunity in Childhood Vaccination

Acta Paediatrica, EarlyView.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Adult-Onset Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome on the Basis of Selective IgA Deficiency. [PDF]

Case Rep Dermatol Med
Altiner S, Ekinci A.
europepmc   +1 more source

Screen‐Detected Coeliac Disease in a Nationally Representative Cohort: Health Indicators, Long‐Term Outcomes and Mortality

Alimentary Pharmacology &Therapeutics, EarlyView.
In a nationally representative Finnish cohort, screen‐detected coeliac disease was associated with iron deficiency, anaemia, and an atherogenic lipid profile at diagnosis, but long‐term gluten‐free treatment did not adversely affect quality of life, metabolic health, or mortality; supporting a favourable benefit‐harm balance for population‐based ...
Iida Ahonen, Kalle Kurppa, Heini Huhtala, Katri Kaukinen, Laura Kivelä, Juha Taavela   +5 more
wiley   +1 more source

Autoimmunity complicating SARS-CoV-2 infection in selective IgA-deficiency. [PDF]

Neurol Neuroimmunol Neuroinflamm, 2020
Pfeuffer S, Pawlowski M, Joos GS, Minnerup J, Meuth SG, Dziewas R, Wiendl H.   +6 more
europepmc   +1 more source

Dupilumab in Cholinergic Urticaria: An Exploratory Phase 2 Investigator‐Initiated Study

Allergy, EarlyView.
Annika Gutsche, Weronika Grabowska, Sabine Altrichter, Eva Grekowitz, Stephanie Roll, Guido Heine, Petra Staubach, Wolfgang Pfützner, Randolf Brehler, Andrea Bauer, Nicola Wagner, Gerda Wurpts, Pascale Salameh, Ali Salehzadeh‐Yazdi, Samad S. Jahandideh, Martin Metz   +15 more
wiley   +1 more source

Increased anergic B cells and decreased antibody‐secreting cells during romiplostim treatment in patients with immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Patients with immune thrombocytopenia (ITP) exhibit substantial heterogeneity in treatment responses. Approximately 30%–50% of patients maintain remission after discontinuation of thrombopoietin receptor agonists (TPO‐RA), suggesting immunomodulatory effects beyond enhanced thrombopoiesis.
Vivianne S. Nelson, Rebeca Gutiérrez‐Cózar, Rebecca Cornelis, S. Marieke van Ham, Anja ten Brinke, Rick Kapur   +5 more
wiley   +1 more source

Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia—Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups

British Journal of Haematology, EarlyView.
Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN12610000060044) was conducted in Australia and France to assess the effect of
Thérèse Aurran‐Schleinitz, Rémi Letestu, Mary Sartor, Stephen Mulligan, Marie C. Béné, Gavin Cull, Dennis Carney, William Renwick, Andrew Grigg, Cecily Forsyth, Gregory Hapgood, Emma Verner, Rosemary Harrup, Pauline Warburton, Kylie Mason, Richard Eek, Wojciech Janowski, Jean Pierre Vilque, Maya Latimer, Laurent Voillat, Sophie De Guibert, Bernard Drenou, Robert Blum, Caroline Dartigeas, Lachlan Hayes, Nicolas Daguindau, Mourad Tiab, Véronique Leblond, Andrew Shearer, Masa Lasica, Pierre Morel, Bohrane Slama, Anne Banos, Annie Brion, Emmanuelle Ferrant, Jessica Michel, Cécile Tomowiak, Edward Morris, Hanlon Sia, Kelly Kratzing, Belinda E. Butcher, Abdelmalek Dahmani, Stephen Robert Larsen, Piers Blombery, Florence Cymbalista, David J. Gottlieb   +45 more
wiley   +1 more source

Volume Quantization with Flexible Singularities for Hexahedral Meshing

Computer Graphics Forum, EarlyView.
Abstract We present a novel algorithm for quantization and subsequent hexahedral mesh generation from seamless volumetric maps. Quantization is the process of choosing integers that represent the numbers of hexahedral elements to be placed in each region of the volume, and transforming the seamless map into an integer‐grid map matching that choice ...
H. Brückler, M. Campen
wiley   +1 more source

Gene Signature of Regulatory T Cells Isolated from Children with Selective IgA Deficiency and Common Variable Immunodeficiency. [PDF]

Cells
Rutkowska-Zapała M, Grabowska-Gurgul A, Lenart M, Szaflarska A, Kluczewska A, Mach-Tomalska M, Baj-Krzyworzeka M, Siedlar M.   +7 more
europepmc   +1 more source