Results 91 to 100 of about 25,700 (219)

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, Volume 13, Issue 46, 17 August 2026.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source

Genetic‐Proteomic Integration Identifies Predictive Plasma Proteins for Multiple Sclerosis

Annals of Neurology, Volume 100, Issue 2, Page 268-281, August 2026.
Objective Multiple sclerosis (MS) develops after a prolonged preclinical phase. Identifying circulating biomarkers that capture this early biology can improve risk stratification and guide intervention. We aimed to identify plasma proteins driving MS susceptibility using large‐scale proteogenomic integration and to evaluate their prediagnostic ...
Yuan Ding, Dylan Hamitouche, Simon Thebault, Patrick Kearns, Ahmed Abdelhak, Adil Harroud   +5 more
wiley   +1 more source

Improvement of Fibromyalgia by Immunoglobulin/Histamine Complex Therapy for Chronic Urticaria and Allergic Rhinitis: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread musculoskeletal pain, often accompanied by fatigue, sleep disturbance, and cognitive symptoms. Although several treatment options are available, no curative therapy has been established.
Hyuk Soon Kim, Yunyoung Nam, Jeong Eun Sohn, Geunwoong Noh   +3 more
wiley   +1 more source

IgD [PDF]

, 2020
openaire   +1 more source

ADAMTS4 mediates LPS‐induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
• ADAMTS4 is induced primarily in cardiac fibroblasts during sepsis. • ADAMTS4 cleaves TSP1 at the 236–246 aa functional region. • TSP1 cleavage activates TGF‐β/Smad and NF‐κB signalling in fibroblasts. • Targeting ADAMTS4 reduces fibroblast activation and cardiac fibrosis.
Zhe‐Wei Zhang, Shi‐Yan Wan, Wen Li, Xiao Lu, Rong Chen, Xin Xing, Wei Lai, Shu‐Yang Sheng, M. M. Mosebetsi, Qing‐Tao Meng, Zi‐Long Lu, Di Fan, Wan‐Li Jiang   +12 more
wiley   +1 more source

IgD myeloma. [PDF]

BMJ, 1968
G, Bert, F, Fontana
openaire   +2 more sources

Expression and Role of the RNA‐Binding Protein, ZFP36L1, in Mouse T Follicular Helper Cell Differentiation and Function

European Journal of Immunology, Volume 56, Issue 8, August 2026.
T follicular helper (Tfh) cells support germinal center (GC) B cells, generating long‐lived antibody‐secreting and memory B cells. RNA‐binding proteins likely fine‐tune Tfh function, but selective deletion of ZFP36L1 from Tfh cells alters neither their differentiation nor GC responses. This suggests further redundancy within the ZFP36 family.
Helena A. Carslaw, Sam Woolliscroft, Emily M. Watson, Sarah E. Bell, Michelle A. Linterman, Martin Turner, Louise M. C. Webb   +6 more
wiley   +1 more source

IgM+IgD− B cells in human gut-associated lymphoid tissue have memory features and give rise to IgM+ and IgA+ antibody-secreting cells

Scientific Reports
Human IgM+ B cells vary in their surface levels of IgD, with the major circulating population of IgM+IgD+ cells and a minor population (
Ameera M. Bukhari, Wenzhao Meng, Aaron M. Rosenfeld, Eline T. Luning Prak, Katherine L. Knight   +4 more
doaj   +1 more source

IgD’s role in vivo [PDF]

Nature Immunology, 2018
openaire   +2 more sources

Keratan Sulfate: An Electroconductive Glycosaminoglycan at the Interface of Sensory Perception and Neural Signaling

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley   +1 more source