Results 61 to 70 of about 21,502,425 (295)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

IGF-I in the clinics: Use in retinopathy of prematurity [PDF]

, 2016
Retinopathy of prematurity is a potentially blinding disease, which is associated with low neonatal IGF-I serum concentrations and poor growth. In severe cases impaired retinal vessel growth is followed by pathologic neovascularization, which may lead to
Ramenghi, LA, Ley, David,, Hellstrom A., Smith, Lois E H, Lofqvist C., Hard, A-L, Hansen-Pupp, Ingrid,, Smith, Lois E.H., Hard, A. L., Hård, Anna-Lena, Hansen-Pupp I., Ingrid Hansen-Pupp, Hård, Anna Lena,, Ramenghi L. A., Hellstrom, A, Ley, D, Hansen-Pupp, Ingrid, Smith, Lois E H,, Ley, D., Smith, L. E. H., Hard A. -L., Lofqvist, C, Ley, David, Hansen-Pupp, I., Hallberg, Boubou,, Hellström, Ann, Lois E.H. Smith, Lund University., Ramenghi, L. A., Hallberg, Boubou, Hansen-Pupp, I, Löfqvist, Chatarina, Anna-Lena Hård, Löfqvist, Chatarina,, Ann Hellström, Hård, Anna Lena, Luca A. Ramenghi, Hellström, Ann,, Ramenghi, Luca A., Hallberg, B,, David Ley, Smith, LEH, Chatarina Löfqvist, Ramenghi, Luca A.,, Hallberg B., Boubou Hallberg, Smith L. E. H., Hallberg, B., Ley D.   +48 more
core   +1 more source

Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2019
Background: Alterations in insulin-like growth factor I (IGF-I) signaling have been associated with dementia and Alzheimer’s disease (AD). Studies on the association between IGF-I levels and dementia risk have been inconclusive.
Sara A. Galle, Sara A. Galle, Ashley van der Spek, Madeleine L. Drent, Madeleine L. Drent, Michael P. Brugts, Erik J. A. Scherder, Joseph A. M. J. L. Janssen, M. Arfan Ikram, M. Arfan Ikram, M. Arfan Ikram, Cornelia M. van Duijn, Cornelia M. van Duijn   +12 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Substrate-bound insulin-like growth factor (IGF)-I-IGF binding protein-vitronectin-stimulated breast cell migration is enhanced by coactivation of the phosphatidylinositide 3-Kinase/AKT pathway by alphav-integrins and the IGF-I receptor [PDF]

, 2007
IGF-I can bind to the extracellular matrix protein vitronectin (VN) through the involvement of IGF-binding proteins-2, -3, -4, and -5. Because IGF-I and VN have established roles in tumor cell dissemination, we were keen to investigate the functional ...
Hollier, Brett G., Derek R. Van Lonkhuyzen, Brett G. Hollier, Leavesley, David I., Kricker, Jennifer A., David I. Leavesley, Zee Upton, Van Lonkhuyzen, Derek R., Jennifer A. Kricker, Upton, Zee   +9 more
core   +1 more source

A quantitative PCR measurement of messenger RNA expression of IGF-I, IGF-II and IGFBP-5 in human skeletal muscle

, 1999
Insulin-like growth factor-I and -II (IGF-I and IGF-II) and their binding proteins are important components in growth promotion and tissue maintenance.
Coenen Schimke, J. M.,, Sarkar, G.,, Conover, C. A.,, Nair, K. S.,, Ljungqvist, Olle,   +4 more
core   +2 more sources

Hepatic mRNA expression and plasma levels of insulin-like growth factor-I (IGF-I) in broiler chickens selected for different growth rates

Genetics and Molecular Biology, 2004
The hepatic expression and plasma concentrations of IGF-I were investigated in three broiler chicken strains selected for different growth rates (HP-Hubbard-Pettersen, a fast growing strain; NN-Naked-neck, a strain with an intermediate growth rate and a ...
Poliana Fernanda Giachetto, Eduardo Correa Riedel, Jane Eyre Gabriel, Maria Inês Tiraboschi Ferro, Sônia Marli Zingaretti Di Mauro, Marcos Macari, Jesus Aparecido Ferro   +6 more
doaj   +1 more source

Transcriptional regulation of the IGF signaling pathway by amino acids and insulin-like growth factors during myogenesis in Atlantic salmon. [PDF]

PLoS ONE, 2010
The insulin-like growth factor signalling pathway is an important regulator of skeletal muscle growth. We examined the mRNA expression of components of the insulin-like growth factor (IGF) signalling pathway as well as Fibroblast Growth Factor 2 (FGF2 ...
Neil I Bower, Ian A Johnston
doaj   +1 more source

Fabrication Routes for Ionic Conducting Fiber Strain Sensors

Advanced Engineering Materials, EarlyView.
Ionic conducting fiber strain sensors (ICFSs) offer compliant, textile‐integrable sensing. Thus far, the commercialization of ICFSs has been constrained by fiber fabrication routes. This review provides a fabrication‐centric analysis of ICFSs correlating processing strategies with material properties and scalability.
Leo John Kershaw, Zhanhong Yang, Anne Ladegaard Skov, Magdalena Skowyra   +3 more
wiley   +1 more source

Erythropoiesis, serum erythropoietin, and serum IGF-I in rats during accelerated growth [PDF]

, 1990
In this study we have examined the correlation between activity of erythropoiesis and serum concentrations of erythropoietin and insulin-like growth factor I in male and female rats during accelerated growth (day 30-90).
Kurtz, Armin, Zapf, J., Matter, R., Eckardt, Kai-Uwe   +3 more
core   +1 more source