Results 301 to 310 of about 396,798 (411)
Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS‐STING Pathway and Reverses Macrophage‐Like VSMC Phenotypes in Progeroid DNA‐Repair‐Deficient Ercc1Δ/− Mice
Aging Cell, EarlyView.Dietary restriction mitigates vascular aging in DNA‐repair‐deficient Ercc1Δ/− mice by reducing extracellular matrix remodeling, inflammation, oxidative stress, and switching of vascular smooth muscle cells to a macrophage‐like phenotype. Our findings suggest that the cGAS‐STING pathway plays a key role in vascular aging and that the benefits of dietary S. J. M. Stefens, J. van der Linden, J. M. Heredia‐Genestar, R. M. C. Brandt, S. Barnhoorn, I. Nieuwenhuizen‐Bakker, N. van Vliet, J. H. M. Odijk, Y. Ridwan, D. Stuijts, M. Batenburg, J. H. J. Hoeijmakers, R. Kanaar, J. Essers, I. van der Pluijm +14 morewiley +1 more sourceThe 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging
Aging Cell, EarlyView.Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health‐promoting trait (more common in women) linked to strong immune resilience and high expression of TCF7, a key immune gene. This trait enables individuals to fight infections like COVID‐19 more effectively, respond Muthu Saravanan Manoharan, Grace C. Lee, Nathan Harper, Justin A. Meunier, Marcos I. Restrepo, Fabio Jimenez, Sreenath Karekatt, Anne P. Branum, Alvaro A. Gaitan, Kian Andampour, Alisha M. Smith, Michael Mader, Michelle Noronha, Devjit Tripathy, Nu Zhang, Alvaro G. Moreira, Lavanya Pandranki, South Texas Veterans Health Care System (STVHCS) COVID‐19 Clinical team, STVHCS COVID‐19 Vaccine team, STVHCS COVID‐19 Convalescent care team, STVHCS Center for Personalized Medicine, Sandra Sanchez‐Reilly, Hanh D. Trinh, Clea Barnett, Luis Angel, Leopoldo N. Segal, Susannah Nicholson, Robert A. Clark, Weijing He, Jason F. Okulicz, Sunil K. Ahuja, Andrew Carrillo, Chanda Dhami, Gaeun Jo, Krupa Jiva, Ernesto Robinson, Caitlyn A. Winter, Lauryn A. Winter, Erin Stewart, Joseph M. Yabes, Peter Melby, Cody R. Butler, Mohamed I. Abdalla, Sandra G. Adams, Yemi Adebayo, Joseph Agnew, Saleem Ali, Gregory Anstead, Antonio Anzueto, Marichu Balmes, Jennifer Barker, Raymond Benavides, Velma Bible, Angela Birdwell, Stacy Braddy, Stephen Bradford, Heather Briggs, Jose A. Cadena Zuluaga, Judith Marin‐Corral, Jennifer J. Dacus, Patrick J. Danaher, Scott A. DePaul, Jill Dickerson, Jollynn Doanne, Samantha Elbel, Miguel Escalante, Corina Escamilla, Valerie Escamilla, Robert Farrar, David Feldman, Debra Flores, Julianne Flynn, Delvina Ford, Joanna D. Foy, Megan Freeman, Samantha Galley, Jessica Garcia, Maritza Garza, Sherraine Gilman, Melanie Goel, Jennifer Gomez, Varun K. Goyal, Sally Grassmuck, Susan Grigsby, Joshua Hanson, Brande Harris, Audrey Haywood, Joan M. Hecht, Cecilia Hinojosa, Tony T. Ho, Teri Hopkins, Aneela N. Hussain, Ali Jabur, Pamela Jewell, Thomas B. Johnson, Austin C. Lawler, Monica Lee, Chadwick S. Lester, Stephanie M. Levine, Haidee V. Lewis, Angel Louder, Charmaine Mainor, Rachel Maldonado, Celida Martinez, Yvette Martinez, Chloe Mata, Neil McElligott, Laura Medlin, Myra Mireles, Joanna Moreno, Kathleen Morneau, Julie Muetz, Samuel B. Munro, Charlotte Murray, Anoop Nambiar, Daniel Nassery, Robert Nathanson, Kimberly Oakman, Jane O’Rorke, Cheryl Padgett, Sergi Pascual‐Guardia, Marisa Patterson, Graciela L. Perez, Rogelio Perez, Jay I. Peters, Rogelio Perez III, Robert E. Phillips, Patrick B. Polk, Michael A. Pomager, Kristy J. Preston, Kevin C. Proud, Jacqueline A. Pugh, Michelle Rangel, Temple A. Ratcliffe, Renee L. Reichelderfer, Evan M. Renz, Jeanette Ross, Teresa Rudd, Maria E. Sanchez, Tammy Sanders, Kevin C. Schindler, David Schmit, Raj T. Sehgal, Claudio Solorzano, Nilam Soni, Win S. Tam, Edward J. Tovar, Sadie A. Trammell Velasquez, Anna R. Tyler, Anjuli Vasquez, Maria C. Veloso, Steven G. Venticinque, Jorge A. Villalpando, Melissa Villanueva, Lauren Villegas, Megan Walker, Andrew Wallace, Maria Wallace, Emily Wang, Stephanie Wickizer, Andreia Williamson, Andrea Yunes, Katharine H. Zentner, Azaneth Arellanes, Ashley B. Banfield, Stephanie N. Bolan‐Reding, Roxanne Colazo, Katherine S. DeLeon, Norma G. Diaz, Mario A. Garza, Raed Kadhume, Hue Mang, Erwin Paleracio, Robert F. Quitta, Laura J. Ramirez, Marzieh Salehi, Cynthia J. Varela +176 morewiley +1 more sourceCathepsin B Regulates Ovarian Reserve Quality and Quantity via Mitophagy by Modulating IGF1R Turnover
Aging Cell, EarlyView.Autophagy regulates ovarian reserve, with Cathepsin B playing a critical role in aging. Inhibition of Cathepsin B increases follicle count, enhances IGF1R–AKT–mTOR signaling and improves mitochondrial function without compromising fertility. This conserved mechanism suggests potential therapeutic strategies to delay ovarian aging and sustain fertility, Aradhana Mohanty, Anjali Kumari, Lava Kumar. S, Ajith Kumar, Pravin Birajdar, Rohit Beniwal, Mohd Athar, Kiran Kumar. P, H.B.D.Prasada Rao +8 morewiley +1 more source
