Results 311 to 320 of about 396,798 (411)

Single‐Cell RNA‐Seq Reveals Aging‐Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury

Aging Cell, EarlyView.
Microglia engage with apoptotic cells via cell‐surface receptors, such as proto‐oncogene tyrosine‐protein kinase MER (MerTK) and Axl; these receptors interact with the bridging molecule growth arrest‐specific 6 (Gas6) on apoptotic cells. Young microglia demonstrate efficient efferocytosis of apoptotic cells, but this process is impaired in aged ...
Pan Liu, Qi Wang, Shuimiao Wang, Ying Liu, Qiqi Chen, Wanyun Qin, Xinna Liu, Xinqi Ye, Yexuan Jiao, Huiping Yuan, Zhengbo Shao   +10 more
wiley   +1 more source

Expression of Insulin-Like Growth Factor-I (IGF-l) and its Receptor in the Peri-Implantation Mouse Uterus, and Cell-Specific Regulation of IGF-l Gene Expression by Estradiol and Progesterone1

, 1992
Suman Kapur, H. Tamada, Sudhansu K. Dey, Glen K. Andrews   +3 more
openalex   +1 more source

ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds

Aging Cell, EarlyView.
ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan, Hongxia Cai, Fang Ye, Wentao Xu, Zhihang Huang, Jingyuan Zhu, Yiwen Gong, Yutong Li, Anastasia Ngozi Ezemaduka, Shan Gao, Shunqi Liu, Guojun Li, Hao Li, Jing Yang, Junyu Ning, Bo Xian   +15 more
wiley   +1 more source

Effects of Treatment on Structural and Functional Parameters of the Left Heart in Naïve Acromegaly Patients: Prospective Single-Centre Study: 12-Month Follow-Up. [PDF]

J Clin Med
Ságová I, Bolek T, Dragula M, Péč MJ, Benko J, Jurica J, Tonhajzerová I, Kantárová D, Mokáň M, Vaňuga P, Samoš M.   +10 more
europepmc   +1 more source

A Novel GH Deficient Rat Model Reveals Cross‐Species Insights Into Aging

Aging Cell, EarlyView.
Mouse studies show disrupted GH signaling reduces body size, increases longevity, and improves health. We developed a CRISPR/Cas9 GH‐deficient rat model to address inconsistent rat evidence. GH‐deficient rats mirrored these findings, showing reduced body weight, increased body fat, enhanced insulin sensitivity, and altered gut microbiomes.
Soe Maung Maung Phone Myint, Alexander Tate Lasher, Kaimao Liu, Aron M. Geurts, Steven N. Austad, Liou Y. Sun   +5 more
wiley   +1 more source

Inhibition of IGF-1Rα affects the differentiation fate of rat optic cup-derived retinal stem cells to retinal ganglion cells <i>in vitro</i>. [PDF]

Int J Ophthalmol
Li QY, Tan XL, Xu HW, Zeng YX, Huang XY.
europepmc   +1 more source

The role and implication of platelet‐rich plasma in male factor infertility: A systematic review of human studies

Andrology, EarlyView.
Abstract Background Cryopreservation causes sperm injury and the success of surgical sperm retrieval (SSR) for azoospermic men is just over half depending on the cause of azoospermia. The role of autologous platelet‐rich plasma (PRP) in male factor infertility (MFI) is unclear. Objective To conduct a systematic review of the role of PRP in MFI focusing
Karl H. Pang
wiley   +1 more source

HBx/WDR5 enhances IGF-1 transcription in hepatocellular carcinoma cells and promotes recruitment, infiltration, and activity of Treg cells. [PDF]

Immunol Res
Wang E, Sun S, Li H, Jia Y, Bai Z.
europepmc   +1 more source

Endocrine Abnormalities and Growth Pattern in Single Large‐Scale Mitochondrial DNA Deletion Syndromes

Acta Paediatrica, EarlyView.
ABSTRACT Aim To assess the prevalence of endocrine disorders and investigate growth patterns in single large‐scale mitochondrial DNA deletion syndromes (SLSMDs). Methods A retrospective study of all children with SLSMD who attended Sheba Medical Center, Israel, from February 2017 to September 2024.
Ayman Daka, Einat Lahav, Omer Bar Yosef, Yoav Bolkier, Yael Levy‐Shraga, Yair Anikster, Elad Jacoby, Noah Gruber   +7 more
wiley   +1 more source

Hormonal regulation of bovine liver and skeletal muscle IGF-1 mRNA

, 1990
Kevin Hannon
openalex   +2 more sources