Effects of IGF-1 on the IGFB proteins level in the serum of obese male rats [PDF]
Insulin-like growth factor binding (IGFB) proteins are a group of six highly conserved proteins that bind to insulin-like growth factors (IGFs) and transport them through the bloodstream to the target cells. The IGFB proteins play an important role in regulating IGF signaling pathways by lengthening their half-life. Obesity and associated disorders are
Obradović, Milan +6 more
core +5 more sources
Continuous and early prediction of future moderate and severe Acute Kidney Injury in critically ill patients: Development and multi-centric, multi-national external validation of a machine-learning model. [PDF]
PLoS One, 2023 Background Acute Kidney Injury (AKI) is a major complication in patients admitted to Intensive Care Units (ICU), causing both clinical and economic burden on the healthcare system. This study develops a novel machine-learning (ML) model to predict, with
Alfieri F +7 more
europepmc +3 more sources
TGF‐Beta Blockade Increases Renal Inflammation Caused by the C‐Terminal Module of the CCN2
Mediators of Inflammation, Volume 2015, Issue 1, 2015., 2015 The CCN family member 2 (CCN2, also known as connective tissue growth factor) may behave as a risk biomarker and a potential therapeutic target for renal disease. CCN2 participates in the regulation of inflammation and fibrosis. TGF‐β is considered the main fibrogenic cytokine; however, in some pathological settings TGF‐β also has anti‐inflammatory ...
Raquel Rodrigues-Díez +8 more
wiley +1 more source
Analytical Cellular Pathology, Volume 2015, Issue 1, 2015., 2015 Breast cancer is the most common type of cancer for women worldwide with a lifetime risk amounting to a staggering total of 10%. It is well established that the endogenous synthesis of insulin‐like growth factor (IGF) and epidermal growth factor (EGF) polypeptide growth factors are closely correlated to malignant transformation and all the steps of the
Kallirroi Voudouri +5 more
wiley +1 more source
International Journal of Endocrinology, Volume 2010, Issue 1, 2010., 2010 Increased concentrations of circulating insulin‐like growth factor‐I (IGF‐I) or IGF‐I relative to IGF‐binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a low‐intensity exercise program on circulating levels of
Yuichiro Nishida +7 more
wiley +1 more source
Evaluation of a large-scale aptamer proteomics platform among patients with kidney failure on dialysis. [PDF]
PLoS One, 2023 Ren Y +9 more
europepmc +1 more source
High-throughput proteomic characterization of seminal plasma from bulls with contrasting semen quality. [PDF]
3 Biotech, 2023 Elango K +9 more
europepmc +1 more source
Evaluation serum levels of Insulin Growth Factor-1 (IGF-1) and its association with clinical parameters in severe COVID-19. [PDF]
Inflammopharmacology, 2022 Feizollahi P +5 more
europepmc +1 more source
How are Aging and Osteoarthritis Related? [PDF]
Aging Dis, 2023 Wakale S +6 more
europepmc +1 more source
A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization. [PDF]
CJC Open, 2021 Bourgeois R +20 more
europepmc +1 more source