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CARD9 EKSİKLİĞİ ve IgG4-RD BİRLİKTELİĞİ
Amaç: Kronik mukokutanöz kandidiazis ve sistemik kandidiyazise sebep olan CARD9 eksikliği, nadirgörülen bir immün yetmezliktir. İmmünglobulin G4 ile ilişkili hastalık (IgG4-RD), birden fazla organıetkileyebilen immün aracılı fibroinflamatuar durumdur.
Harmancı, Koray +7 more
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Therapy of immunoglonuline IgG4 related disease (IgG4-RD)
Vnitřní lékařství, 2022Immunoglobulin IgG4 related disease (IgG4-RD) is a heterogeneous disorder with multi-organ involvement recognised as a separate entity at the beginning of this century only. Evolving therapy is reviewed in this paper. Glucocorticoids are first choice drug but long administration of glucocorticoids is connected with many adverse effects.
Zdeněk, Adam +12 more
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Current Opinion in Rheumatology, 2012
Provide an update of the developments in IgG4 related disease within the last year in terms of nomenclature, diagnostic criteria and clinical features.The number of diseases associated with IgG4 related disease continues to grow. The entities of idiopathic orbital inflammation, idiopathic cervical fibrosis, eosinophilic angiocentric fibrosis, reactive ...
Mollie N, Carruthers +2 more
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Provide an update of the developments in IgG4 related disease within the last year in terms of nomenclature, diagnostic criteria and clinical features.The number of diseases associated with IgG4 related disease continues to grow. The entities of idiopathic orbital inflammation, idiopathic cervical fibrosis, eosinophilic angiocentric fibrosis, reactive ...
Mollie N, Carruthers +2 more
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The protean manifestations of IgG4-RD in gastrointestinal disorders
Disease-a-Month, 2015Immunoglobulin G4-related disease (IgG4-RD) is a recently recognized fibroinflammatory condition characterized by a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, extensive fibrosis with a characteristic “storiform” pattern, and usually, elevated serum IgG4 concentrations.
Avik, Sarkar, Capecomorin S, Pitchumoni
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2023
IgG4-related disease has been manifested with fibrosis, inflammation and deregulated metabolism clinical symptoms. In this study, we have investigated the molecular mechanism of aforementioned clinical symptoms with PBMC from IgG4-RD patients, IgG4 cells lines and USP25 KO mice.
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IgG4-related disease has been manifested with fibrosis, inflammation and deregulated metabolism clinical symptoms. In this study, we have investigated the molecular mechanism of aforementioned clinical symptoms with PBMC from IgG4-RD patients, IgG4 cells lines and USP25 KO mice.
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Mechanism of fibrogenesis in submandibular glands in patients with IgG4-RD
Journal of Molecular Histology, 2018The aim of this study was to investigate the mechanisms driving fibrosis in the submandibular glands (SMG) of patients with IgG4-related disease (IgG4-RD). Immunohistochemistry showed that many fibroblast-like cells expressing IL-6, IL-18, TSLP, IL-33, and MMP1 were present in SMG from the affected patients.
Ryoto, Yajima +9 more
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Coronary periarteritis in IgG4-RD: A case series
Clinical RheumatologyIgG4-related disease (IgG4-RD) can affect multiple organ systems, with coronary artery involvement being rare. Coronary periarteritis may lead to complications such as myocardial infarction and ischemic cardiomyopathy. This case series characterizes the clinical and radiological features, complications, and treatment strategies in patients with IgG4-RD-
Georges El Hasbani +3 more
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Immunologische Grundlagen der IgG4-RD
Der Radiologe, 2016IgG4 bindet nicht wie die anderen IgG-Subklassen an niedrigaffine Fc-Rezeptoren und aktiviert nicht die klassische Komplementkaskade. Es ist zudem instabil und kann spontan in 2 Hemimolekule zerfallen. Auch wenn diese Daten fur eine immunsuppressive Rolle des IgG4 sprechen, gibt es andererseits wenige Beispiele, in denen IgG4-Antikorper eine ...
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Diagnostic Challenges in a Case of IgG4-RD Affecting the Temporal Bone
Annals of Otology, Rhinology & Laryngology, 2016Introduction: Immunoglobulin G4–related disease (IgG4-RD) is a recently described fibroinflammatory condition with a characteristic histology. While IgG4-RD can affect a great variety of anatomical sites, it has been seldom described in the temporal bone.
Jackson Ross, Vuncannon +3 more
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