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IgG subclass deficiency with or without IgA deficiency
Clinical Immunology and Immunopathology, 1991IgG subclass deficiency (IgGSD) is difficult to define since reference materials vary between laboratories and the clinically relevant cut off levels for the various subclasses are not well known. The diagnosis of IgGSD should be based on more than one determination since the levels vary, due to various factors such as infections, operations, etc ...
L. Å. Hanson +7 more
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Pediatric Allergy and Immunology, 1991
The different biological properties of human IgG subclasses make each subclass unique in its functional role in either resistance to infection, autoimmune diseases or allergy. Not only are there marked differences in the relative concentrations of IgG subclasses in serum (IgG1> IgG2> IgG3/IgG4) but the distribution of the antibody responses in ...
L. J. Beard +2 more
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The different biological properties of human IgG subclasses make each subclass unique in its functional role in either resistance to infection, autoimmune diseases or allergy. Not only are there marked differences in the relative concentrations of IgG subclasses in serum (IgG1> IgG2> IgG3/IgG4) but the distribution of the antibody responses in ...
L. J. Beard +2 more
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Allergy and Asthma Proceedings, 1992
IgG subclasses have been recognized since the early 1960s. Four such subclasses, designated IgG1, IgG2, IgG3, and IgG4, are known to exist. Approximately 65 to 70% of the total circulating IgG in normal persons is of the IgG1 subclass. IgG2 constitutes 20 to 25% of circulating IgG, and IgG3 and IgG4 each represent less than 10%.
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IgG subclasses have been recognized since the early 1960s. Four such subclasses, designated IgG1, IgG2, IgG3, and IgG4, are known to exist. Approximately 65 to 70% of the total circulating IgG in normal persons is of the IgG1 subclass. IgG2 constitutes 20 to 25% of circulating IgG, and IgG3 and IgG4 each represent less than 10%.
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Molecular basis of IgG subclass deficiency
Immunological Reviews, 2000IgG subclass deficiency was recognized as a separate disease entity in the early seventies and was shown to be associated with an increased susceptibility to infections. Although deletions of the corresponding gamma genes have been demonstrated in a few cases, a majority of patients suffer from a regulatory dysfunction, and the deficiencies are most ...
Qiang Pan, Lennart Hammarström
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IgG subclass deficiencies associated with bronchiectasis.
American Journal of Respiratory and Critical Care Medicine, 1996Only a small number of patients with IgG subclass deficiencies (IgGSD) have been observed to have bronchiectasis. Moreover, in the series of patients with bronchiectasis, IgGSD have not been found at any frequency, and the etiology of bronchiectasis remains unclear in 29 to 49% of cases.
J. de Gracia +7 more
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IgG deficiency in association with placental oedema
Early Human Development, 1977Deficiency of the immunoglobulin C (IgG) in the human newborn is rare in the absence of maternal hypogammaglobulinaemia. Low concentrations of IgG in cord blood were found in 3 conditions--the donor twin in the fetofetal transfusion syndrome, hydrops fetalis and congenital hepatic disease. These were all associated with placental oedema.
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IgG immunoglobulin deficiency in muscular dystrophic chickens
Journal of Heredity, 1977Plasma immunoglobulin profiles of New Hampshire strain muscular dystrophic chickens were determined by radial immunodiffusion, immunoelectrophoresis and polyacrylamide gel electrophoresis. Muscular dystrophic chickens have reduced levels of IgG but maintain normal levels of total serum proteins, IgA and IgM. The relationship and significance of the IgG
Kimberly Kline, Bob G. Sanders
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IgG subclass deficiency in children with recurrent bronchitis
European Journal of Pediatrics, 1992We studied the incidence of IgG subclass deficiency in children with recurrent bronchitis. Recurrent bronchitis was defined as three or more episodes a year during at least 2 consecutive years, of bronchopulmonary infection, productive cough with or without fever and/or diffuse râles by physical examination in the absence of asthma or atopy.
J. Kint +3 more
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IgG subclass deficiency in amyotrophic lateral sclerosis
Acta Neurologica Scandinavica, 2009In order to get to clues about T-cell independent versus T-cell dependent immune mechanism in ALS, we measured IgG subclasses in 25 ALS-patients: 16 patients had deficiency of T-cell dependent expressed IgG1 or IgG3 or both with essentially normal levels of T-cell independent expressed IgG2 and IgG4.
Bernard M. Patten +1 more
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IgG subclass deficiencies in children: Facts and fiction
Pediatric Allergy and Immunology, 2017AbstractThe chance to analyse the four IgG subclasses arose with the publication of Terry and Fahey1. Since then, a lot of new information on the role of subclasses and their deficiency states in humans has been obtained. This review tries to analyse critically our current knowledge of subclass deficiencies in children.
Horst von Bernuth, Volker Wahn
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