Results 71 to 80 of about 259,280 (346)

Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury. [PDF]

, 2019
Acute kidney injury (AKI) can be fatal and is a well-defined risk factor for the development of chronic kidney disease. Group 2 innate lymphoid cells (ILC2s) are innate producers of type-2 cytokines and are critical regulators of homeostasis in ...
Cameron, Guy JM, Cautivo, Kelly M, Deshpande, Aniruddh V, Foster, Paul S, Hansbro, Philip M, Jiang, Simon H, Loering, Svenja, McKenzie, Andrew NJ, Molofsky, Ari B, Starkey, Malcolm R   +9 more
core   +4 more sources

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Audit of immunoglobulin monitoring and hypogammaglobulinaemia after B cell targeted therapy in a paediatric cohort in a high immune disease prevalence Region

Clinical Medicine
Introduction: Secondary hypogammaglobulinaemia or antibody deficiency (SAD) is an under-recognised complication of B cell-targeted therapies (BCTTs) in both autoimmune diseases (AIDs) and haematological malignancy.
Khadija Karim, Omar Mostafa, Alaa Samarh, Sharon Bout-Tabaku, Buthaina Al-Adba, Ahmad Kaddourah, Abubakr Imam, Ibrahim Shatat, Bajes Hamad, Mahmoud Fawzi, Ruba Benini, Ayman Saleh, Tayseer Yousif, Areeg Ahmed, Yasmin El Bsat, Bernice Lo, Mohammed Yousuf Karim   +16 more
doaj   +1 more source

Salmonella typhi vaccination response study reveals defective antibody production selective IgA deficiency patient

Revista Alergia México, 2015
Selective IgA deficiency (SIgAD) is the most prevalent immunodeficiency worldwide, progressing to common variable immunodeficiency only in few reported cases.
Daniel E Pleguezuelo, Carla Gianelli
doaj   +1 more source

Intradermal immunization with wall teichoic acid (WTA) elicits and augments an anti-WTA IgG response that protects mice from methicillin-resistant Staphylococcus aureus infection independent of mannose-binding lectin status. [PDF]

PLoS ONE, 2013
The objectives of this study were to investigate the immune response to intradermal immunization with wall teichoic acid (WTA) and the effect of MBL deficiency in a murine model of infection with methicillin-resistant Staphylococcus aureus (MRSA). WTA is
Kazue Takahashi, Kenji Kurokawa, Patience Moyo, Dong-Jun Jung, Jang-Hyun An, Lorencia Chigweshe, Elahna Paul, Bok Luel Lee   +7 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

CONCENTRATIONS OF IgG SUBCLASSES IN ALLOGENEIC BONE MARROW RECIPIENTS

Медицинская иммунология, 2014
A sufficient increase of infectious complications rate during early posttransplant period in allogeneic bone marrow (allo-BM) recipients has been traditionally explained by the prominent drop of serum IgG levels in the patients.
A. V. Klimovich, M. T. Van Lint, M. P. Samoilovich, B. V. Afanasiev, V. B. Klimovich   +4 more
doaj   +1 more source

PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells [PDF]

, 2019
Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR).
Althoff, Till F., Burghaus, Jana, Cao Ho, Thanh, Jürgensen, Lonny, Kamuf-Schenk, Verena, Katus, Hugo A., Kiper, Leon, Krull, Alexandros, Riechert, Eva, Schecker, Johannes, Stangl, Karl, Stangl, Verena, Völkers, Mirko, Wöltje, Kerstin, Zhang, Kevin Sun   +14 more
core   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Enzyme replacement therapy with taliglucerase alfa: 36-month safety and efficacy results in adult patients with Gaucher disease previously treated with imiglucerase. [PDF]

, 2016
Taliglucerase alfa is the first available plant cell-expressed human recombinant therapeutic protein. It is indicated for treatment of patients with type 1 Gaucher disease (GD) in adult and pediatric patients in several countries.
Amato, Dominick J, Brill-Almon, Einat, Chertkoff, Raul, Giraldo, Pilar, Pastores, Gregory M, Petakov, Milan, Rosenbaum, Hanna, Shankar, Suma P, Szer, Jeffrey, Zimran, Ari   +9 more
core   +2 more sources