Results 171 to 180 of about 659,736 (328)

Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell   +8 more
wiley   +1 more source

Social Frailty in Heart Failure: Concept, Impact and Preventive Strategies

open access: yesJournal of Advanced Nursing, Volume 82, Issue 2, Page 1819-1826, February 2026.
ABSTRACT Aims To explore the conceptualisation of social frailty and discuss its role in shaping the disease trajectory of heart failure. Based on the discussion, recommendations on how to prevent and manage social frailty in this clinical cohort are delineated. Design A discursive paper.
Miao Miao   +2 more
wiley   +1 more source

Isolation and Characterisation of Serotype III in Miamiensis avidus (Ciliophora: Scuticociliatida) From Olive Flounder (Paralichthys olivaceus)

open access: yesJournal of Fish Diseases, Volume 49, Issue 2, February 2026.
ABSTRACT Miamiensis avidus (Ciliophora: Scuticociliatida, syn. Philasterides dicentrarchi) is a significant pathogen causing scuticociliatosis in olive flounder (Paralichthys olivaceus) in Korea and Japan. In this study, the BB19 strain, isolated from olive flounder, was identified as M.
Jin‐Young Kim   +5 more
wiley   +1 more source

El traslado de la capital del Reino de Guatemala (1773-1779). Conflicto de poder y juegos sociales

open access: yesRevista de Historia, 2008
Según los propios términos de los Ministros de la Real Audiencia, la decisión de reconstruir, en un lugar diferente, una nueva capital en la Capitanía General de Guatemala, tras los terremotos de 1773 provocó uno de los mayores asuntos que habrán ...
Christophe Belaubre
doaj  

Synoptic Features Driving the CO2 Sink in the Mediterranean Sea in Winter

open access: yesJournal of Geophysical Research: Atmospheres, Volume 131, Issue 2, 28 January 2026.
Abstract The Mediterranean Sea is a weak sink for the atmospheric CO2 with the October‐March extended winter season characterized by the occurrence of high CO2 sink events. Here, we analyzed state‐of‐the‐art ocean and atmospheric reanalyses and observational data sets to investigate the variability of the winter sink and its relation with synoptic ...
M. Reale   +4 more
wiley   +1 more source

Impact of patient safety on hospital prognosis: Association between adverse events and in-hospital mortalit. [PDF]

open access: yesClin Med (Lond)
Roncal-Redin M   +7 more
europepmc   +1 more source

Enhancer‐dependent gene regulation in space, time, and malignancies

open access: yesInternational Journal of Cancer, Volume 158, Issue 2, Page 357-367, 15 January 2026.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum   +2 more
wiley   +1 more source

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